Author

B. P. Nicolet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 10 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 9 Approach:experimental assay· 8 Assay:bulk RNA-seq· 7 Research Focus:cell type annotation· 5 Assay:proteomics· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 3

Frequent Co-Authors

A. Guislain· 7 shared M. C. Wolkers· 7 shared J. J. Freen-van Heeren· 4 shared F. Salerno· 3 shared M. Wolkers· 3 shared M. van den Biggelaar· 2 shared S. Engels· 2 shared A. Bradaric· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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7 shared papersImmunology

A. Guislain

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Learning the sequence code of protein expression in human immune cells

B. P. Nicolet, A. Jurgens, K. Bresser, A. Guislain, A. Bradaric, M. Wolkers

SONAR, a machine learning pipeline, learns the sequence code for protein abundance in human immune cells, revealing cell type-specific and activation-dependent sequence features that can enhance T cell receptor expression.

bioRxiv · Sep 1, 2023Immunology

Re-use of labware reduces CO2 equivalent footprint and running costs in laboratories

M. Farley, B. P. Nicolet

This study compares the CO2 equivalent footprint and costs of single-use plastics versus reusable glass/plastic labware, finding re-use reduces CO2e up to 11-fold and has lower or comparable running costs.

bioRxiv · Jan 14, 2022 · PreprintCell Biology

Time-dependent regulation of cytokine production by RNA binding proteins defines T cell effector function

B. Popovic, B. P. Nicolet, A. Guislain, S. Engels, A. P. Jurgens, N. Paravinja, J. J. Freen-van Heeren, F. P. van Alphen, M. van den Biggelaar, F. Salerno, M. C. Wolkers

The paper identifies RNA binding proteins regulating cytokine production in T cells over time, showing how they influence effector function and anti-tumor responses.

bioRxiv · Nov 3, 2021Immunology

Mapping RNA-binding proteins in human B cells and Tcells upon differentiation

N. D. Zandhuis, B. P. Nicolet, M. C. Wolkers

The paper maps RNA-binding protein (RBP) expression in human B and T cells during differentiation, revealing cell-type-specific and differentiation-dependent patterns.

bioRxiv · Jun 10, 2021 · PreprintImmunology

CD29 enriches for cytotoxic human CD4+ T cells

B. P. Nicolet, A. Guislain, M. C. Wolkers

The paper identifies CD29 as a marker to enrich for cytotoxic human CD4+ T cells, showing they express cytotoxic genes and kill target cells.

bioRxiv · Feb 10, 2021Immunology

The relationship of mRNA with protein expression in CD8+ T cells associates with gene class and gene characteristics

B. P. Nicolet, M. C. Wolkers

The study finds that mRNA expression poorly predicts protein levels in CD8+ T cells, but gene class and characteristics like sequence conservation and UTR length influence this relationship.

bioRxiv · Apr 21, 2020Immunology

CD29 marks superior cytotoxic human CD8+ T cells

B. P. Nicolet, A. Guislain, F. P. J. van Alphen, R. Gomez-Eerland, T. N. M. Schumacher, M. van den Biggelaar, M. Wolkers

This study identifies CD29 as a marker for cytotoxic CD8+ T cells, showing its stability and utility in enhancing anti-tumoral activity.

bioRxiv · Aug 9, 2019Immunology

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

R. de Groot, M. M. van Loenen, A. Guislain, B. P. Nicolet, J. J. Freen-van Heeren, O. Verhagen, M. M. van den Heuvel, J. de Jong, P. Burger, E. van der Schoot, R. M. Spaapen, D. Amsen, J. B. Haanen, K. Monkhorst, K. J. Hartemink, M. C. Wolkers

The paper isolates and expands tumor-reactive T cells from NSCLC tumors, finding that polyfunctional T cells correlate with immune-engaged T cell profiles and tumor reactivity.

bioRxiv · Jun 8, 2019Immunology

Costimulation through TLR2 drives polyfunctional CD8+ T cell responses

F. Salerno, J. J. Freen-van Heeren, A. Guislain, B. P. Nicolet, M. Wolkers

This study shows TLR2 ligands lower antigen thresholds for cytokine production and enhance polyfunctional CD8+ T cell responses through mRNA stabilization and costimulation.

bioRxiv · Nov 5, 2018Immunology

Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells

F. Salerno, A. Guislain, J. J. Freen-van Heeren, B. P. Nicolet, H. A. Young, M. C. Wolkers

The paper shows that post-transcriptional regulation, specifically mRNA stability, limits IFN-γ production in tumor-infiltrating T cells, and restoring this stability enhances anti-tumor effects.

bioRxiv · Jun 24, 2018Immunology

Circular RNA expression in human hematopoietic cells is widespread and cell-type specific

B. P. Nicolet, S. Engels, F. Aglialoro, E. van den Akker, M. M. von Lindern, M. C. Wolkers

The paper analyzes circRNA expression in human hematopoietic cells, finding cell-type specific patterns and increased expression during maturation.

bioRxiv · Apr 12, 2018Immunology