Author

B. Popovic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:CITE-seq· 1

Frequent Co-Authors

A. Guislain· 3 shared M. C. Wolkers· 3 shared J. J. Freen-van Heeren· 2 shared S. Engels· 2 shared A. Buchanan· 1 shared A. P. Jurgens· 1 shared A. Popalzij· 1 shared B. P. Nicolet· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

A. Guislain

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Regulation of IFNgamma production by ZFP36L2 in T cells is context-dependent

N. D. Zandhuis, A. Guislain, A. Popalzij, S. Engels, B. Popovic, M. Turner, M. C. Wolkers

This study shows ZFP36L2 regulates IFNγ production in T cells differently depending on activation context and time, by destabilizing Ifng mRNA in an AU-rich element-dependent manner.

bioRxiv · Feb 9, 2024 · PreprintImmunology

Time-dependent regulation of cytokine production by RNA binding proteins defines T cell effector function

B. Popovic, B. P. Nicolet, A. Guislain, S. Engels, A. P. Jurgens, N. Paravinja, J. J. Freen-van Heeren, F. P. van Alphen, M. van den Biggelaar, F. Salerno, M. C. Wolkers

The paper identifies RNA binding proteins regulating cytokine production in T cells over time, showing how they influence effector function and anti-tumor responses.

bioRxiv · Nov 3, 2021Immunology

In vitro Evolution of Antibody Affinity via Insertional Mutagenesis Scanning of an Entire Antibody Variable Region

K. Skamaki, S. Emond, M. Chodorge, J. Andrews, D. G. Rees, D. Cannon, B. Popovic, A. Buchanan, R. Minter, F. Hollfelder

This paper demonstrates that insertional mutagenesis can enhance antibody affinity, achieving a 256-fold improvement in an anti-IL-13 antibody through InDel mutagenesis combined with point mutations.

bioRxiv · Apr 26, 2020Biochemistry

Human T cells employ conserved AU-rich elements to fine-tune IFN-γ production

J. J. Freen-van Heeren, B. Popovic, A. Guislain, M. C. Wolkers

This study shows that AU-rich elements in the IFNG 3UTR regulate IFN-γ production in human T cells, with ARE deletion increasing sustained cytokine production and anti-tumor responses.

bioRxiv · Nov 4, 2019Immunology