Author

J. J. H. Chu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. Y. Wang· 2 shared K. S. Tan· 2 shared B. A. Ahidjo· 1 shared B. Chen· 1 shared B. Reversade· 1 shared B. V. Au· 1 shared C. K. Lim· 1 shared C. K. Mok· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

D. Y. Wang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Broadly neutralizing and protective nanobodies against diverse sarbecoviruses

M. Li, Y. Ren, Z. Q. Aw, B. Chen, Z. Yang, Y. Lei, L. Cheng, Q. Liang, J. Hong, Y. Yang, J. Chen, Y. H. Wong, S. Shan, S. Zhang, J. Ge, , L. Zhang

The paper identifies nanobodies with broad neutralizing activity against multiple sarbecoviruses and shows their protective efficacy in a mouse model.

bioRxiv · Apr 12, 2022 · PreprintImmunology

miR-573 rescues endothelial dysfunction during dengue infection under PPARγ regulation.

S. Banerjee, C. Wein Xin, J. J. H. Chu

This study identifies miR-573 as a regulator of endothelial dysfunction in dengue infection, showing it reduces permeability and inflammation by targeting ANGPT2 and TLR2.

bioRxiv · Aug 30, 2021Microbiology

Direct cleavage of human NLRP1 by enteroviral 3C protease triggers inflammasome activation in airway epithelium

K. Robinson, D. E. T. Teo, K. S. Tan, G. A. Toh, H. H. Ong, C. K. Lim, K. Lay, B. V. Au, T. S. Lew, J. J. H. Chu, V. T. K. Chow, D. Y. Wang, F. L. Zhong, B. Reversade

The paper identifies enteroviral 3C proteases as the first cognate PAMP ligand for human NLRP1, showing they trigger inflammasome activation and airway inflammation.

bioRxiv · Oct 14, 2020 · PreprintImmunology

Calcitriol, the active form of vitamin D, is a promising candidate for COVID-19 prophylaxis

C. K. Mok, Y. L. Ng, B. A. Ahidjo, R. C. H. Lee, M. W. C. Loe, J. Liu, K. S. Tan, P. Kaur, W. J. Chng, J. E. L. Wong, D. Y. Wang, E. W. Hao, X. Hao, Y. W. Tan, T. M. Mak, , J. J. H. Chu

This study identifies calcitriol, the active form of vitamin D, as a potent inhibitor of SARS-CoV-2, suggesting its potential as a prophylactic agent against COVID-19.

bioRxiv · Jun 21, 2020 · PreprintMicrobiology