Author

J. J. Kobie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:mouse· 1

Frequent Co-Authors

L. Martinez-Sobrido· 4 shared M. R. Walter· 4 shared A. Deshpande· 3 shared C. Ye· 3 shared J.-G. Park· 3 shared M. Basu· 3 shared M. S. Piepenbrink· 3 shared A. Loos· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

L. Martinez-Sobrido

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Potent universal-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody

M. S. Piepenbrink, J.-G. Park, A. Deshpande, A. Loos, C. Ye, M. Basu, S. Sarkar, D. Chauvin, J. Woo, P. Lovalenti, N. B. Erdmann, P. A. Goepfert, V. L. Truong, R. A. Bowen, M. R. Walter, , J. J. Kobie

This study identifies a potent universal coronavirus neutralizing monoclonal antibody, 1249A8, effective against multiple variants and demonstrating therapeutic activity through intranasal administration.

bioRxiv · Mar 5, 2022 · PreprintImmunology

Mixed Origins: HIV gp120-specific memory develops from pre-existing memory and naive B cells following vaccination in humans

M. Basu, M. S. Piepenbrink, C. Fucile, C. A. Bunce, L.-X. Man, J. Liesveld, A. F. Rosenberg, M. C. Keefer, J. J. Kobie

This study shows that HIV gp120-specific memory B cells arise from both naive and pre-existing cross-reactive memory B cells following vaccination.

bioRxiv · Sep 1, 2021Immunology

Epitope classification and RBD binding properties of neutralizing antibodies against SARS-CoV-2 variants of concern

A. Deshpande, B. D. Harris, L. Martinez-Sobrido, J. J. Kobie, M. R. Walter

This study classifies NAb epitopes against SARS-CoV-2 RBD and evaluates how variants affect NAb and ACE2 binding, identifying key mutations that impact neutralization and infectivity.

bioRxiv · Apr 13, 2021Immunology

Generation and Characterization of recombinant SARS-CoV-2 expressing reporter genes

K. Chiem, D. Morales Vasquez, J.-G. Park, R. N. Platt, T. Anderson, M. R. Walter, J. J. Kobie, C. Ye, L. Martinez-Sobrido

This paper generates and characterizes recombinant SARS-CoV-2 viruses expressing fluorescent or bioluminescent reporter genes, demonstrating their utility for tracking viral infection and screening therapeutics.

bioRxiv · Nov 16, 2020Microbiology

Therapeutic activity of an inhaled potent SARS-CoV-2 neutralizing human monoclonal antibody in hamsters

M. S. Piepenbrink, J.-G. Park, F. Oladunni, A. Deshpande, M. Basu, S. Sarkar, A. Loos, J. Woo, P. Lovalenti, D. Sloan, C. Ye, K. Chiem, N. B. Erdmann, P. A. Goepfert, V. L. Truong, , J. J. Kobie

This study evaluates an inhaled monoclonal antibody against SARS-CoV-2 in hamsters, showing reduced viral burden and lung pathology with low-dose inhalation.

bioRxiv · Oct 14, 2020Immunology