Author

R. A. Bowen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 3 Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 7 Organism:mouse· 6 Assay:proteomics· 3 Organism:human· 2 Organism:rat· 2 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1

Frequent Co-Authors

H. Bielefeldt-Ohmann· 3 shared A. E. Hartwig· 2 shared A. M. Bosco-Lauth· 2 shared A. Tuanyok· 2 shared B. J. Currie· 2 shared H. Hornstra· 2 shared I. K. Ragan· 2 shared P. Gordy· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersBiochemistry

H. Bielefeldt-Ohmann

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Potent universal-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody

M. S. Piepenbrink, J.-G. Park, A. Deshpande, A. Loos, C. Ye, M. Basu, S. Sarkar, D. Chauvin, J. Woo, P. Lovalenti, N. B. Erdmann, P. A. Goepfert, V. L. Truong, R. A. Bowen, M. R. Walter, , J. J. Kobie

This study identifies a potent universal coronavirus neutralizing monoclonal antibody, 1249A8, effective against multiple variants and demonstrating therapeutic activity through intranasal administration.

bioRxiv · Mar 5, 2022 · PreprintImmunology

Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological and pathological disease in a Syrian hamster model of COVID-19

T. J. Esparza, Y. Chen, N. P. Martin, H. Bielefeldt-Ohmann, R. A. Bowen, W. D. Tolbert, M. J. Pazgier, D. L. Brody

This study shows that nebulized NIH-CoVnb-112 nanobody reduces weight loss, viral burden, and lung pathology in Syrian hamsters infected with SARS-CoV-2.

bioRxiv · Nov 10, 2021Biochemistry

An alphavirus replicon-based vaccine expressing a stabilized Spike antigen induces sterile immunity and prevents transmission of SARS-CoV-2 between cats

M. A. Langereis, K. Stachura, S. Miller, A. M. Bosco-Lauth, I. C. Albulescu, A. E. Hartwig, S. M. Porter, J. Stammen-Vogelzangs, M. Mogler, F. J. M. van Kuppeveld, B. J. Bosch, P. Vermeij, A. de Groof, R. A. Bowen, R. Davis, , I. Tarpey

This paper develops a replicon-based vaccine that prevents SARS-CoV-2 infection and transmission in cats.

bioRxiv · Apr 1, 2021Microbiology

Survey of peridomestic mammal susceptibility to SARS-CoV-2 infection

A. Bosco-Lauth, J. J. Root, S. Porter, A. Walker, L. Guilbert, D. Hawvermale, A. Pepper, R. Maison, A. Hartwig, P. Gordy, H. Bielefeldt-Ohmann, R. A. Bowen

This study investigates susceptibility of peridomestic mammals to SARS-CoV-2 infection, finding some species can be infected and shed the virus while others are not susceptible.

bioRxiv · Jan 21, 2021 · PreprintMicrobiology

Replicating bacterium-vectored vaccine expressing SARS-CoV-2 Membrane and Nucleocapsid proteins protects against severe COVID-19 disease in hamsters

M. A. Horwitz, Q. A. Jia, H. Bielefeldt-Ohmann, R. Maison, S. Maslesa-Galic, R. A. Bowen

bioRxiv · Nov 17, 2020Immunology

A Whole Virion Vaccine for COVID-19 Produced Via a Novel Inactivation Method: Results from Animal Challenge Model Studies

I. K. Ragan, L. M. Hartson, T. S. Dutt, A. Obregon-Henao, R. M. Maison, P. Gordy, A. Fox, B. R. Karger, S. T. Cross, M. L. Kapuscinski, S. K. Cooper, B. K. Podell, M. D. Stenglein, R. A. Bowen, M. Henao-Tamayo, R. Goodrich

This paper evaluates a novel inactivated whole virion COVID-19 vaccine (SolaVAX) in hamsters, showing its ability to induce neutralizing antibodies and protect against SARS-CoV-2 infection.

bioRxiv · Nov 13, 2020Immunology

Pathogenesis, transmission and response to re-exposure of SARS-CoV-2 in domestic cats

A. M. Bosco-Lauth, A. E. Hartwig, S. M. Porter, P. W. Gordy, M. Nehring, A. D. Byas, S. VandeWoude, I. K. Ragan, R. M. Maison, R. A. Bowen

This study investigates SARS-CoV-2 susceptibility, transmission, and immune response in domestic cats and dogs, finding cats can be infected subclinically and transmit the virus but develop immunity to re-infection, while dogs do not shed virus but mount neutralizing antibodies.

bioRxiv · May 28, 2020Microbiology

Pathogen to commensal: longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection

T. Pearson, J. Sahl, C. M. Hepp, K. Handady, H. Hornstra, A. J. Vazquez, E. Settles, M. Mayo, M. Kaestli, C. H. D. Williamson, E. P. Price, D. S. Sarovich, J. M. Cook, S. R. Wolken, R. A. Bowen, , P. Keim

This study tracks the long-term evolution of Burkholderia pseudomallei in a human host over 16 years, showing its transition from a pathogen to a commensal through genetic and phenotypic changes.

bioRxiv · Feb 17, 2019Evolutionary Biology

Caprine humoral response to Burkholderia pseudomallei antigens during acute melioidosis from aerosol exposure

J. Yi, M. F. Simpanya, E. W. Settles, A. B. Shannon, K. Hernandez, L. Pristo, M. Keener, H. Hornstra, J. D. Busch, C. Soffler, P. J. Brett, B. J. Currie, R. A. Bowen, A. Tuanyok, P. Keim

This study characterizes the caprine humoral immune response to Burkholderia pseudomallei during aerosol-induced melioidosis, identifying immunogenic proteins that may serve as diagnostic biomarkers.

bioRxiv · Sep 17, 2018Immunology