P. Chopra

Chemoenzymatic Synthesis of Heparan Sulfate Oligosaccharides having a Domain Structure

This study develops a chemoenzymatic method to synthesize HS oligosaccharides with defined NS and NA domains, showing that NA domain length affects chemokine binding.

Structure, immunogenicity, and conformation-dependent receptor binding of the post-fusion human metapneumovirus F protein

This study determines the structure of post-fusion hMPV B2 F protein, assesses its receptor binding and immunogenicity, and shows it induces neutralizing antibodies against multiple hMPV strains.

Sialic acid-Dependent Binding and Viral Entry of SARS-CoV-2

This study shows SARS-CoV-2 RBD binds sialylated glycans, particularly gangliosides, and that reducing cell surface sialic acid decreases viral entry.

Heparan sulfate proteoglycans as attachment factor for SARS-CoV-2

This study identifies heparan sulfate proteoglycans as an attachment factor for SARS-CoV-2 and suggests HS oligosaccharides could inhibit viral binding.

A novel redox-active switch in Fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily

This study identifies redox-sensitive cysteines in Fructosamine-3-kinases (FN3Ks) that regulate their activity and dimerization through disulfide bonds, revealing a novel redox regulatory mechanism in the protein kinase superfamily.

Salt-free fractionation of complex isomeric mixtures of glycosaminoglycan oligosaccharides compatible with ESI-MS and microarray analysis

This paper introduces a multi-dimensional separation method for glycosaminoglycan oligosaccharides that enables structural and functional analysis without desalting.