J. Jardine

Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits

The paper discovers synthetic antibodies specific to RGD-binding integrins and identifies their subunit pairing preferences.

Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy

This study shows that necrosulfonamide oxidizes PCM1, disrupts ciliogenesis, and impairs autophagy, highlighting PCM1 as a redox sensor.

HIV skews the SARS-CoV-2 B cell response toward an extrafollicular maturation pathway

This study shows that HIV infection shifts the SARS-CoV-2 B cell response toward an extrafollicular pathway, leading to lower affinity antibodies and reduced vaccine efficacy in people living with HIV.

One-shot identification of SARS-CoV-2 S RBD escape mutants using yeast screening

The paper presents a method to identify SARS-CoV-2 Spike RBD escape mutants using yeast screening and provides associated resources.

A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation.

The paper identifies a USP30 inhibitor that mimics genetic loss of USP30, revealing its role in regulating mitochondrial ubiquitylation and mitophagy through TOM complex components.