Author

A. Leslie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:flow cytometry· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

A. K. Shalek· 2 shared B. Berger· 2 shared D. Ramjit· 2 shared F. Karim· 2 shared R. Krause· 2 shared S. K. Nyquist· 2 shared T. Ndung'u· 2 shared A. A. Tu· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersImmunology

A. K. Shalek

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Author profile →

5 papers

Recent·Most cited

A targeted isotope dilution mass spectrometry assay for Osteopontin quantification in plasma of metastatic breast cancer patients

A. Leslie, E. Teh, A. Drucker, D. M. Pinto

This paper develops a targeted isotope dilution mass spectrometry assay for quantifying osteopontin in plasma of metastatic breast cancer patients, achieving a detection limit of 39 ng/mL.

bioRxiv · Jan 25, 2023Biochemistry

HIV skews the SARS-CoV-2 B cell response toward an extrafollicular maturation pathway

R. Krause, COMMIT-KZN Team, J. Snyman, S.-H. Hwa, D. Muema, F. Karim, Y. Ganga, A. Ngoepe, Y. Zungu, I. Gazy, M. Bernstein, K. Khan, M. Mazibuko, N. Mthabela, D. Ramjit, , A. Leslie

This study shows that HIV infection shifts the SARS-CoV-2 B cell response toward an extrafollicular pathway, leading to lower affinity antibodies and reduced vaccine efficacy in people living with HIV.

bioRxiv · Jun 14, 2022Immunology

Mycobacterium tuberculosis senses host Interferon- gamma via the membrane protein MmpL10

M. Ahmed, J. S. Mackenzie, R. Krause, B. Truebody, L. B. Tezera, D. Garay-Baquero, A. F. Vallejo, K. Govender, J. Adamson, P. Elkington, A. J. C. Steyn, A. Leslie

This study shows Mycobacterium tuberculosis senses IFN-γ via MmpL10, increasing respiration and virulence, and enhances INH efficacy against persistent bacteria.

bioRxiv · Nov 12, 2021Microbiology

HIV-specific CD8+ T-cells in tonsils express exhaustive TRM-like signatures

R. Fardoos, S. K. Nyquist, O. E. Asowata, S. W. Kazer, A. Singh, A. N. Ngoepe, J. G. Giandhari, N. M. Mthabela, D. Ramjit, S. Singh, F. Karim, S. Buus, F. Anderson, J. Z. Porterfield, A. L. Sibiya, , H. N. Kloverpris

The paper examines HIV-specific CD8+ T-cells in tonsils, finding they exhibit TRM-like exhaustion signatures compared to blood, with differences in natural HIV controllers.

bioRxiv · Nov 4, 2021 · PreprintImmunology

Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control

H. P. Gideon, T. K. Hughes, C. N. Tzouanas, M. H. Wadsworth, A. A. Tu, T. M. Gierahn, J. M. Peters, F. H. Hopkins, J.-R. Wei, C. Kummerlowe, N. L. Grant, K. Nargan, J. Phuah, H. J. Borish, P. Maiello, , A. K. Shalek

The paper identifies cellular and temporal factors associated with bacterial control in tuberculosis granulomas using multimodal data.

bioRxiv · Oct 24, 2020 · PreprintImmunology