Author

S.-H. Hwa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Assay:imaging· 1

Frequent Co-Authors

A. Sigal· 4 shared M. Bernstein· 3 shared Y. Ganga· 3 shared COMMIT-KZN Team· 2 shared F. Karim· 2 shared H. Rodel· 2 shared K. Khan· 2 shared W. Hanekom· 2 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersImmunology

A. Sigal

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

HIV skews the SARS-CoV-2 B cell response toward an extrafollicular maturation pathway

R. Krause, COMMIT-KZN Team, J. Snyman, S.-H. Hwa, D. Muema, F. Karim, Y. Ganga, A. Ngoepe, Y. Zungu, I. Gazy, M. Bernstein, K. Khan, M. Mazibuko, N. Mthabela, D. Ramjit, , A. Leslie

This study shows that HIV infection shifts the SARS-CoV-2 B cell response toward an extrafollicular pathway, leading to lower affinity antibodies and reduced vaccine efficacy in people living with HIV.

bioRxiv · Jun 14, 2022Immunology

SARS-CoV-2 cell-to-cell spread occurs rapidly and is insensitive to antibody neutralization

L. Jackson, H. Rodel, S.-H. Hwa, S. Cele, Y. Ganga, H. Tegally, M. Bernstein, J. Giandhari, COMMIT-KZN Team, B. I. Gosnell, K. Khan, W. Hanekom, F. Karim, T. de Oliveira, M.-Y. S. Moosa, A. Sigal

This study shows SARS-CoV-2 spreads rapidly between cells via fusion and is resistant to antibody neutralization, unlike cell-free virus.

bioRxiv · Jun 1, 2021 · PreprintMicrobiology

Development of highly potent neutralising nanobodies against multiple SARS-CoV-2 variants including the variant of concern B.1.351

A. M. Sziemel, S.-H. Hwa, A. Sigal, G. Tyson, N. Logan, B. J. Willett, P. J. Durcan

This paper develops potent neutralizing nanobodies against SARS-CoV-2 variants, including B.1.351, to address reduced vaccine efficacy.

bioRxiv · Apr 11, 2021 · PreprintImmunology

Aggregated Mycobacterium tuberculosis enhances the inflammatory response

A. Sigal, H. Rodel, I. M. Ferreira, C. Ziegler, Y. Ganga, M. Bernstein, S.-H. Hwa, G. Kaplan, G. Lustig, K. Nargan, M. Noursadeghi, A. Steyn, A. K. Shalek

The paper investigates how aggregated Mycobacterium tuberculosis triggers a stronger inflammatory response in macrophages compared to single or multiple non-aggregated bacilli.

bioRxiv · Mar 23, 2021Microbiology