Author

Y. Ganga

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1 Assay:imaging· 1

Frequent Co-Authors

A. Sigal· 4 shared F. Karim· 3 shared K. Khan· 3 shared M. Bernstein· 3 shared S.-H. Hwa· 3 shared COMMIT-KZN Team· 2 shared G. Lustig· 2 shared H. Rodel· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersMicrobiology

A. Sigal

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

HIV skews the SARS-CoV-2 B cell response toward an extrafollicular maturation pathway

R. Krause, COMMIT-KZN Team, J. Snyman, S.-H. Hwa, D. Muema, F. Karim, Y. Ganga, A. Ngoepe, Y. Zungu, I. Gazy, M. Bernstein, K. Khan, M. Mazibuko, N. Mthabela, D. Ramjit, , A. Leslie

This study shows that HIV infection shifts the SARS-CoV-2 B cell response toward an extrafollicular pathway, leading to lower affinity antibodies and reduced vaccine efficacy in people living with HIV.

bioRxiv · Jun 14, 2022Immunology

SARS-CoV-2 cell-to-cell spread occurs rapidly and is insensitive to antibody neutralization

L. Jackson, H. Rodel, S.-H. Hwa, S. Cele, Y. Ganga, H. Tegally, M. Bernstein, J. Giandhari, COMMIT-KZN Team, B. I. Gosnell, K. Khan, W. Hanekom, F. Karim, T. de Oliveira, M.-Y. S. Moosa, A. Sigal

This study shows SARS-CoV-2 spreads rapidly between cells via fusion and is resistant to antibody neutralization, unlike cell-free virus.

bioRxiv · Jun 1, 2021 · PreprintMicrobiology

Aggregated Mycobacterium tuberculosis enhances the inflammatory response

A. Sigal, H. Rodel, I. M. Ferreira, C. Ziegler, Y. Ganga, M. Bernstein, S.-H. Hwa, G. Kaplan, G. Lustig, K. Nargan, M. Noursadeghi, A. Steyn, A. K. Shalek

The paper investigates how aggregated Mycobacterium tuberculosis triggers a stronger inflammatory response in macrophages compared to single or multiple non-aggregated bacilli.

bioRxiv · Mar 23, 2021Microbiology

The CNS in the face of ART contains T cell origin HIV which can lead to drug resistance

G. Lustig, S. Cele, F. Karim, Y. Ganga, K. Khan, B. Gosnell, Y. Moosa, R. Harrichandparsad, S. Marais, R. Gupta, A. Derache, J. Giandhari, T. de Oliveira, K. Govender, J. Adamson, , A. Sigal

The paper investigates the origin of HIV in the CNS of ART-suppressed individuals and finds T cell-derived HIV that can lead to drug resistance.

bioRxiv · Mar 25, 2019 · PreprintMicrobiology