Author

J. A. Triccas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 5 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1

Frequent Co-Authors

C. Counoupas· 5 shared A. Aggarwal· 3 shared M. Steain· 3 shared W. J. Britton· 3 shared A. Ashhurst· 2 shared A. Stella· 2 shared C. Ashley· 2 shared G. Nagalingam· 2 shared

Activity by Year

2020-2021 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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5 shared papersImmunology

C. Counoupas

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Neutralising antibodies against the SARS-CoV-2 Delta variant induced by Alhydroxyquim-II-adjuvanted trimeric spike antigens

C. Counoupas, P. Pino, A. Stella, C. Ashley, H. Lukeman, N. Bhattacharyya, T. Tada, S. Anchisi, C. Metayer, J. Martinis, A. Aggarwal, B. Dcosta, J. Kint, M. Wurm, N. Landau, , J. A. Triccas

This study shows that Alhydroxiquim-II-adjuvanted trimeric spike antigens induce high-titre, cross-variant neutralising antibodies against SARS-CoV-2 in animal models.

bioRxiv · Aug 18, 2021Microbiology

Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein using mRNA Display

A. Norman, C. Franck, M. Christie, P. Hawkins, K. Patel, A. Ashhurst, A. Aggarwal, J. K. Low, R. Siddiquee, C. Ashley, M. Steain, J. A. Triccas, S. G. Turville, J. Mackay, T. Passioura, R. J. Payne

The paper identifies cyclic peptide ligands to the SARS-CoV-2 spike protein RBD using mRNA display, finding six high-affinity molecules with nanomolar dissociation constants.

ACS Central Science · Jun 23, 2021Peer-reviewedBiochemistry

A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilizing immunity against SARS-CoV-2 infection in mice

C. Counoupas, M. D. Johnson, A. Stella, D. H. Nguyen, A. Ferguson, A. Aggarwal, N. Bhattacharyya, A. Grey, K. Patel, R. Siddiquee, E. L. Stewart, O. Hutchings, C. Feng, N. G. G. Hansbro, U. Palendira, , J. A. Triccas

A BCG-adjuvanted vaccine provides sterilizing immunity against SARS-CoV-2 in mice, with high neutralizing antibody titers and Th1 responses.

bioRxiv · Dec 10, 2020 · PreprintMicrobiology

Advax adjuvant formulations promote protective immunity against aerosol Mycobacterium tuberculosis in the absence of deleterious inflammation and reactogenicity

D. H. Quan, C. Counoupas, G. Nagalingam, R. Pinto, N. Petrovsky, W. J. Britton, J. A. Triccas

This study evaluates Advax adjuvant formulations for tuberculosis vaccine efficacy, showing they provide strong protection without causing inflammation or reactogenicity.

bioRxiv · Oct 1, 2020Immunology

Microbial activation converts neutrophils into anti-tumor effectors

A. O. Yam, J. Bailey, F. Lin, A. Jakovija, C. Counoupas, J. A. Triccas, M. Gunzer, T. Bald, S. T. Grey, T. Chtanova

This study shows microbial bioparticles convert neutrophils into anti-tumor effectors by altering their phenotype and function, leading to tumor growth inhibition.

bioRxiv · Aug 21, 2020 · PreprintImmunology

Rough and smooth variant Mycobacterium abscessus infections are differentially controlled by host immunity during chronic infection of adult zebrafish

E. Hortle, J. Y. Kam, E. Krogman, S. E. Warner, K. Luo, T. Cheng, P. Manuneedhi Cholan, K. Kikuchi, J. A. Triccas, W. J. Britton, M. D. Johansen, L. Kremer, S. H. Oehlers

This study compares immune responses to smooth and rough variants of Mycobacterium abscessus in zebrafish, showing differential control by host immunity.

bioRxiv · Jun 6, 2020 · PreprintMicrobiology

Mucosal delivery of a multistage subunit vaccine promotes development of lung-resident memory T cells and affords interleukin-17-dependant protection against pulmonary tuberculosis

C. Counoupas, K. Ferrell, A. Ashhurst, N. D. Bhattacharyya, G. Nagalingam, C. G. Feng, N. Petrovsky, W. J. Britton, J. A. Triccas

This paper shows that a mucosal vaccine induces lung-resident memory T cells expressing IL-17, which protect against tuberculosis, and that IL-17 is critical for this protection.

bioRxiv · Feb 25, 2020 · PreprintImmunology