J. Lin

This study identifies direct kinase targets of Compound Danshen Dropping Pills using literature, public databases, and in silico models, finding 30 targets at 25 g/ml and 9 dose-dependent targets at 250 g/ml.

This study shows that IRE1 regulates macrophage polarization, PD-L1 expression, and tumor survival in mice and humans.

This study shows P4HA2 is overexpressed in glioma and promotes cancer progression by enhancing proliferation, invasion, migration, and EMT, while also regulating the PI3K/AKT pathway through collagen expression.

This study shows that Bacillus subtilis spore enhances mucosal immunity by promoting intestinal-resident memory T cells through ICAM-1 expression on dendritic cells.

The paper identifies the genetic basis of sex determination in grapevines by analyzing phased genomes and finding a novel male-fertility gene.

This study shows that reducing SIRT2 rescues GARS-induced neuropathy in a Drosophila model by restoring acetylated tubulin levels and axonal transport.

This study investigates how microbial growth traits evolve under serial dilution, finding that growth rate and lag time are subject to selection while yield is not.

This study determines high-resolution structures of E. coli ClpAP complex in substrate-bound states to elucidate the mechanism of protein unfolding and proteolysis coupling.

This study shows anlotinib inhibits drug-resistant colorectal cancer cell proliferation and induces apoptosis by inactivating the PI3K/AKT pathway.

This study identifies FAP57/WDR65 as a docking factor that targets specific inner dynein arms to the 96 nm axonemal repeat and connects to regulatory hubs in cilia.

The study tests whether genetically diverse host populations select for parasites with broader host ranges, finding mixed support for this hypothesis.

This paper describes the preparation of a PLGA-based nano-ultrasound contrast agent conjugated with anti-HER-2 antibody and evaluates its in vitro targeting and imaging performance.

This study shows that the carboxyl-terminal sequence of Bim is necessary for Bax activation and cell killing, independent of anti-apoptotic protein inhibition.

The paper identifies a CXCR5-negative CD4+ T cell subset in HIV-infected lymph nodes that shares lineage and functional traits with CXCR5+ T follicular helper cells.

The paper determines the cryo-EM structure of a hyperactive ClpB variant bound to casein and ATPγS to elucidate its substrate gripping and translocation mechanism.

The paper constructs a gene expression model to explain how protein and mRNA concentrations scale with cell volume in growing cells, finding exponential growth and a transition to linear growth under certain conditions.

This paper shows Bacillus thuringiensis uses Cry toxins and PlcR-regulated virulence factors to disrupt C. elegans intestinal epithelial junctions, enabling successful infection.

This study identifies the oxidative enzyme systems in Polyporus brumalis that enable efficient lignin degradation during wheat straw fermentation.

This study uses single molecule FRET to show Cas9 undergoes conformational changes and long-range allosteric communication that regulate DNA cleavage, identifying key residues for improving CRISPR/Cas9 specificity.

The paper uses cryo-electron tomography to visualize dynein conformations in sea urchin sperm flagella, revealing a mechanism where dynein inhibition generates flagellar beating through asymmetric force distribution.

The paper argues for a new system of post-publication amendments to improve transparency and reduce stigma in academic publishing.

The paper discusses how preprints are viewed differently across research communities and proposes a model to distinguish between the object's state and its standing.

This study predicts the evolutionary pathway of norovirus escaping antibodies using a biophysical fitness model, validated by experimental evolution in bulk culture and microfluidics.