J. Lin

This paper identifies serum proteins that mediate endothelial cell invasion by non-C. albicans Candida species through bridging molecule-mediated endocytosis.

This study identifies key molecular indicators of asparagine deamidation and aspartic acid isomerization in therapeutic antibodies and proposes a physics-based model to predict their propensity.

This paper demonstrates that annealing the 70S ribosome at a fast cooling rate synchronizes it into a minimum-energy conformation, enhancing homogeneity and stability for structural analysis.

This study investigates how exposure route, sex, and age affect SARS-CoV-2 pathogenesis in golden Syrian hamsters, finding significant differences in disease outcomes.

This study identifies proteins interacting with EGFR during C. albicans infection and shows that gC1qR is essential for EGFR signaling and immune responses.

The paper develops an in vitro model of the human esophagus to study ancestral differences in response to bile acid injury, finding significant differences between European American and African American-derived cells.

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

This paper identifies two amiloride derivatives that inhibit bacterial motility across multiple strains and stator types, including both Na+ and H+ powered motors.

This study identifies falcilysin as a target of anti-malaria drugs and reveals a shared inhibitory pocket that could guide new drug development.

The paper maps memory B cell receptors against SARS-CoV-2 spike variants, identifying 7 mAb competition groups and their epitopic regions, and shows their cross-reactivity and neutralization properties.

The paper identifies CDK12 inhibition as a strategy to enhance EGFR blockade efficacy in TNBC by targeting translation and stability of oncoproteins like MYC through 4E-BP1 and CCR4-NOT complex.

The paper analyzes T-cell receptor repertoires in different phases of COVID-19 to identify immune response patterns and predict recurrent infection risk.

This study shows that in Escherichia coli, replication and division are strongly correlated at slow growth rates but become independent at higher growth rates.

This study uses single-cell RNA sequencing to analyze aging-related changes in subcutaneous adipose tissue, revealing shifts in cellular roles and metabolic phenotypes associated with aging.

The paper identifies a novel antiviral chemotype effective against multiple respiratory viruses by targeting a host multi-protein complex involved in viral lifecycle and innate immunity.

This study develops process-based tree phenology models for subtropical trees using experimental data, showing advanced spring phenology under warming with species-specific responses.

The paper identifies two transcription factors, RlmA and Ace1, critical for Aspergillus fumigatus virulence by analyzing gene expression during lung infection in mice.

This study combines CRISPR activation and binary colloidal crystals to enhance the rapid differentiation of human iPSCs into neurons.

This study determines the structure of the Bax core dimer and shows it forms part of the mitochondrial pore wall during apoptosis.

This study shows that C. elegans uses mitochondrial surveillance systems and the AMPK pathway to trigger innate immune responses against bacterial pathogens through non-PRR patterns.

This study examines how wildfire and its legacy through charcoals affect soil microbial communities in boreal forests over a 29-year chronosequence.

This study investigates the radiosensitizing effect of curcumin combined with Glu-GNPs on breast cancer xenografts in nude mice, showing reduced VEGF and HSP90 expression.

This study reveals how target RNA binding regulates Cmr-β complex activities through conformational changes, enabling immune responses against genetic invaders.

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

This study investigates how Candida albicans virulence factors Als3 and Ece1/Candidalysin interact with host receptors EphA2 and EGFR to induce inflammation during oropharyngeal candidiasis.

The paper shows that IMD/Relish suppresses perilipin1, leading to lipid droplet enlargement that reduces ROS stress during bacterial infection in Drosophila.

This study tracks clonal evolution in residual breast cancer tumors and finds that recurrence can arise through distinct evolutionary paths with different clonal compositions and drug sensitivities.

This paper isolates blocking antibodies against SARS-CoV-2 RBD using a competitive biopanning strategy, identifying a high-affinity antibody with potent neutralizing activity.

This study identifies the SiaABC threonine phosphorylation pathway as a regulator of biofilm formation in Pseudomonas aeruginosa in response to carbon availability and surfactant stress.

The paper engineers Hsp104 variants with substrate specificity to selectively reduce alpha-synuclein toxicity in a Parkinson's disease model.