Author

N. Legrave

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:fungi (other)· 1

Frequent Co-Authors

A. Chapuis· 1 shared A. Clear· 1 shared A. D'Avola· 1 shared A. Gunawan· 1 shared A. Mendez-Lucas· 1 shared C. Xie· 1 shared D. Calado· 1 shared D. M. MacCallum· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperMicrobiology

A. Chapuis

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma

A. D'Avola, N. Legrave, M. Tajan, P. Chakravarty, R. Shearer, H. King, E. Cheung, A. Clear, A. Gunawan, L. Zhang, L. James, J. MacRae, J. Gribben, D. Calado, K. Vousden, J. Riches

This study identifies PHGDH as essential for germinal center formation and shows its inhibition reduces lymphoma progression and improves survival.

bioRxiv · Nov 11, 2021Immunology

Identifying strategies to target the metabolic flexibility of tumours.

A. Mendez-Lucas, W. Lin, P. C. Driscoll, N. Legrave, L. Novellasdemunt Vilaseca, C. Xie, M. Charles, Z. Wilson, N. P. Jones, S. G. Rayport, M. Rodriguez-Justo, V. S. W. Li, J. I. MacRae, N. Hay, X. Chen, M. Yuneva

The paper identifies compensatory metabolic mechanisms in tumours and shows that targeting these can improve therapeutic outcomes.

bioRxiv · Jan 6, 2020Cancer Biology

The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis

I. M. Dambuza, T. Drake, A. Chapuis, L. Taylor-Smith, N. LeGrave, T. Rasmussen, M. C. Fisher, T. Bicanic, T. S. Harrison, M. Jaspars, R. C. May, G. D. Brown, R. Yuecel, D. M. MacCallum, E. R. Ballou

This paper establishes an in vitro system to induce Titan cells in Cryptococcus neoformans, identifies bacterial peptidoglycan as an inducer, and shows that Titanisation is regulated and conserved across species.

bioRxiv · Sep 19, 2017Microbiology