Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase
Z. Ji, H. Li, D. Peterle, J. A. Paulo, S. B. Ficarro, T. E. Wales, J. Marto, S. Gygi, J. R. Engen, T. A. Rapoport
This study elucidates how the Cdc48 ATPase complex unfolds and translocates polyubiquitinated protein substrates through cooperative binding with Ufd1/Npl4.
bioRxiv · Oct 21, 2021Biochemistry