T. A. Rapoport

Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation

The paper demonstrates bidirectional substrate shuttling between the 26S proteasome and Cdc48 ATPase in yeast, showing how this process facilitates protein degradation.

The membrane curvature inducing REEP1 proteins generate a novel ER-derived vesicular compartment

This study identifies REEP1 proteins as forming a novel ER-derived vesicular compartment and shows that mutations affecting their curvature-inducing activity lead to relocalization to the bulk ER.

Membrane curvature-generating proteins crucial for autophagosome formation

This study identifies REEP1 proteins as essential for autophagosome formation by stabilizing the high curvature of the phagophore rim.

Mechanism of PEX5-mediated protein import into peroxisomes

This study elucidates how PEX5 mediates protein import into peroxisomes by showing its interaction with the docking complex and ubiquitin ligase, and how it recycles after cargo release.

Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase

This study elucidates how the Cdc48 ATPase complex unfolds and translocates polyubiquitinated protein substrates through cooperative binding with Ufd1/Npl4.

Cryo-EM structure determination of small proteins by nanobody-binding scaffolds (Legobodies)

This paper introduces a method using nanobody-binding scaffolds to determine the structure of small proteins via cryo-EM, demonstrating its effectiveness with the KDEL receptor and SARS-CoV-2 RBD.

Structure and function of accessory Sec proteins involved in the adhesin export pathway of Streptococcus gordonii

This study investigates the sequential O-glycosylation of an adhesin in Streptococcus gordonii and its interaction with accessory Sec proteins for export.