Author

J. Nazarian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. Koschmann· 2 shared A. C. Resnick· 1 shared A. Eze· 1 shared A. Felmeister· 1 shared A. Franson· 1 shared A. J. Waanders· 1 shared A. M. Douglas· 1 shared A. M. Sonabend· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCancer Biology

C. Koschmann

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4 papers

Recent·Most cited

Single-molecule systems for detection and monitoring of plasma circulating nucleosomes and oncoproteins in Diffuse Midline Glioma

N. Erez, N. Furth, V. Fedyuk, J. Wadden, R. Aittaleb, K. Schwark, M. Niculcea, M. Miclea, R. Mody, A. Franson, A. Eze, N. Nourmohammadi, J. Nazarian, S. Venneti, C. Koschmann, E. Shema

This paper develops a single-molecule system to detect and monitor plasma nucleosomes and oncoproteins in Diffuse Midline Glioma patients, showing clinical utility for non-invasive diagnostics.

bioRxiv · Nov 21, 2023Cancer Biology

PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma

R. J. Duchatel, E. R. Jackson, S. G. Parackal, C. Sun, P. Daniel, A. Mannan, I. J. Findlay, D. Staudt, Z. P. Germon, S. Laternser, D. Kiltschewskij, P. S. Kearney, M. F. B. Jamaluddin, A. M. Douglas, T. Beitaki, , M. D. Dun

This study identifies PI3K/mTOR as a targetable genetic dependency in DIPG and demonstrates that combining paxalisib with metformin improves survival in xenograft models.

bioRxiv · Apr 17, 2023Cancer Biology

MSCs Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma

M. Chastkofsky, K. C. Pituch, H. Katagi, L. Ilut, T. Xiao, Y. Han, A. M. Sonabend, D. T. Curiel, E. R. Bonner, J. Nazarian, C. Horbinski, C. D. James, A. Saratsis, R. Hashizume, M. S. Lesniak, I. V. Balyasnikova

This study shows that mesenchymal stem cells can deliver oncolytic virotherapy to DIPG tumors, significantly improving survival when combined with radiotherapy in preclinical models.

bioRxiv · May 9, 2020Cancer Biology

Pediatric High Grade Glioma Resources From the Children’s Brain Tumor Tissue Consortium (CBTTC) and Pediatric Brain Tumor Atlas (PBTA)

H. Ijaz, M. P. Koptyra, K. S. Gaonkar, J. L. Rokita, V. P. Baubet, L. Tauhid, Y. Zhu, M. A. Brown, G. Lopez Garcia, B. Zhang, S. J. Diskin, Z. Vaksman, J. L. Mason, E. M. Appert, J. V. Lilly, , K. A. Cole

This paper describes a resource of pediatric high grade glioma (pHGG) data and biospecimens from the CBTTC and PBTA, including genomic, clinical, and imaging data, along with cell lines and tissue microarrays.

bioRxiv · May 31, 2019Cancer Biology