J. P. Higham

Social ageing can protect against infectious disease in a group-living primate

The paper examines how reduced social connectedness in older primates can mitigate infection risks from a hypothetical pathogen, showing age-related changes in social behavior affect disease dynamics.

GPR35 inhibits TRPA1-mediated colonic afferent hypersensitivity through suppression of Substance P release

This paper identifies GPR35 as a target for non-opioid analgesics by showing it inhibits TRPA1-mediated colonic hypersensitivity through suppression of Substance P release.

Early life adversity has sex-dependent effects on survival across the lifespan in rhesus macaques

This study examines how early life adversity affects survival in male and female rhesus macaques, finding sex-dependent differences in mortality risk across the lifespan.

The biology of aging in a social world: insights from free-ranging rhesus macaques

This paper reviews how social adversity affects aging in rhesus macaques, focusing on ecological and social factors and the impact of Hurricane Maria.

Cost and benefits of being social: examining the influence of sociality on faecal parasites in free-ranging rhesus macaques

This study examines how social relationships affect parasitic infection risk in rhesus macaques, finding that affiliative partners reduce protozoa infection risk, while social status does not.

A generalizable epigenetic clock captures aging in two nonhuman primates.

This paper develops an epigenetic clock for rhesus macaques using DNA methylation data, achieving high accuracy in predicting age across different populations and species.

Sensitisation of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity

This study shows IL-13 sensitizes colonic nociceptors via JAK and p38 MAPK signaling, offering therapeutic targets for visceral pain in gastrointestinal diseases.

Ageing in a collective: The impact of ageing individuals on social network structure

This study examines how ageing affects social network structure in rhesus macaques using empirical data and an agent-based model, finding age-related changes in indirect connectivity but no overall network structure age distribution relationship.

Within-individual changes reveal increasing social selectivity with age in rhesus macaques

This study shows that older female rhesus macaques reduce their social networks and prioritize previously beneficial partners, indicating social selectivity with age.

Reduced injury risk links sociality to survival in a group-living primate

The paper investigates how sociality affects injury risk and survival in rhesus macaques, finding that social integration reduces injury risk but not mortality after injury.

Age, sex, and social environmental effects on immune cell composition in a free-ranging non-human primate.

This study examines how age, sex, and social status affect immune cell composition in rhesus macaques, revealing age-related immunosenescence and sex-dependent effects of social adversity.

Sex-biased gene expression in rhesus macaque and human brains

This study compares sex-biased gene expression in human and rhesus macaque brains across 16 regions, finding limited overlap and greater sexual dimorphism in humans.

The structure of species discrimination signals across a primate radiation

The paper uses machine learning to identify key facial traits for species discrimination in guenons and validates these findings with behavioral experiments.

Experimental evidence that female rhesus macaques (Macaca mulatta) perceive variation in male facial masculinity

This study shows female rhesus macaques spend more time looking at more masculine male faces in controlled experiments, suggesting they can perceive facial masculinity.