H. Takeyama

Metagenomic Insights Reveal Unrecognized Diversity of Entotheonella in Japanese Theonella Sponges

The paper uses metagenomic analysis to uncover previously unrecognized diversity of Entotheonella in Theonella sponges.

Mycelial differentiation linked avermectin production in studied with Raman imaging

This study uses Raman imaging to show how avermectin production correlates with mycelial differentiation stages in Streptomyces avermitilis under different culture conditions.

Variation of length and sequence of the nuclear ribosomal DNA internal transcribed spacer 1 supports hermit-to-king crab hypothesis

The paper analyzes ITS1 length and sequence variation in lithodoid and paguroid crabs to support the hermit-to-king crab hypothesis.

Male-killing-associated bacteriophage WO identified from comparisons of Wolbachia endosymbionts of Homona magnanima

The paper identifies a male-killing-associated bacteriophage WO in Wolbachia strains of Homona magnanima and proposes a mechanism for male-killing evolution.

Targeted single-cell genomics reveals novel host adaptation strategies of the symbiotic bacteria Endozoicomonas in Acropora tenuis coral

This study uses single-cell genomics to analyze Endozoicomonas bacteria in Acropora tenuis corals, revealing host-adaptive genes that may enhance coral stress tolerance.

Revealing within-species diversity in uncultured human gut bacteria with single-cell long-read sequencing

This study develops a single-cell long-read sequencing workflow to generate complete bacterial genomes from uncultured human gut bacteria, revealing structural diversity and phage insertions within species.

Single-cell metabolite detection and genomics reveals uncultivated talented producer

This study identifies an uncultivated bacterium as a producer of antifungal metabolites using Raman microscopy and single-cell sequencing in a sponge microbiome.

Raman microspectroscopy imaging analysis of extracellular vesicles (EVs) biogenesis by filamentous fungus Penicilium chrysogenum

This study uses Raman microspectroscopy to investigate EV biogenesis in Penicillium chrysogenum and shows EVs release penicillin.

Identification of two cancer stem cell-like populations in triple-negative breast cancer xenografts

The paper identifies two cancer stem cell-like populations in TNBC xenografts using transcriptomic analysis and confirms their presence in patient data, suggesting potential as biomarkers and implications for drug resistance.

Recovery of high-quality assembled genomes via metagenome binning guided with single-cell amplified genomes

This paper introduces MetaSAG, a method using single-cell genomes to improve metagenome binning, resulting in higher quality and strain-resolved microbial genomes from complex communities.

Detection of Penicillin G Produced by Penicillium chrysogenum KF 425 in Vivo with Raman Microspectroscopy and Multivariate Curve Resolution-Alternating Least Squares Methods

This study detects penicillin G inside Penicillium chrysogenum KF425 cells using Raman microspectroscopy and MCR-ALS, revealing its subcellular localization for the first time.

Molecular profiling of lipid droplets inside HuH7 Cells with Raman micro-spectroscopy

This study uses Raman micro-spectroscopy with multivariate curve resolution to profile lipid droplet molecular composition in HuH7 cells, revealing structural changes related to cellular physiology.

Single-cell genomics of uncultured bacteria reveals dietary fiber responders in the mouse gut microbiota

This study develops a single-cell genomic sequencing technique to identify bacterial responders to dietary fiber in the mouse gut microbiota, revealing metabolic pathways and functional lineages involved in fiber fermentation.

Time-lapse single-cell transcriptomics reveals modulation of histone H3 for dormancy breaking

The paper uses time-lapse single-cell transcriptomics to show histone H3 gene expression fluctuation is crucial for breaking dormancy in fission yeast spores.