M. Hosokawa

A combination of two-enzyme system and enzyme engineering improved the activity of a new PET hydrolase identified from soil bacterial genome

The paper identifies a novel PET hydrolase from soil bacteria, enhances its activity with CALB and protein engineering, achieving 95.5% PET degradation.

Single Amplified Genome Catalog Reveals the Dynamics of Mobilome and Resistome in the Human Microbiome

The paper presents a dataset of single amplified genomes (SAGs) and metagenome-assembled genomes (MAGs) from the human microbiome, revealing microbial diversity, mobile genetic elements, and antibiotic resistance gene dynamics.

Propagation path of a flowering cherry (Cerasus x yedoensis) cultivar 'Somei-Yoshino' traced by somatic mutations

The paper traces the propagation path of the Somei-Yoshino cherry cultivar by identifying somatic mutations across 46 clones and clustering them into genetic groups.

Uncovering novel endolysins against methicillin-resistant Staphylococcus aureus using microbial single-cell genome sequencing

The paper uses microbial single-cell genome sequencing to discover novel endolysins against methicillin-resistant Staphylococcus aureus, identifying a lead endolysin with effective antimicrobial properties.

Male-killing-associated bacteriophage WO identified from comparisons of Wolbachia endosymbionts of Homona magnanima

The paper identifies a male-killing-associated bacteriophage WO in Wolbachia strains of Homona magnanima and proposes a mechanism for male-killing evolution.

Targeted single-cell genomics reveals novel host adaptation strategies of the symbiotic bacteria Endozoicomonas in Acropora tenuis coral

This study uses single-cell genomics to analyze Endozoicomonas bacteria in Acropora tenuis corals, revealing host-adaptive genes that may enhance coral stress tolerance.

Identification of a novel chalcone reductase gene for isoliquiritigenin biosynthesis in dahlia (Dahlia variabilis)

This study identifies a novel chalcone reductase gene (DvCHR) in dahlia involved in isoliquiritigenin biosynthesis, showing evolutionary divergence from legume CHR genes.

Revealing within-species diversity in uncultured human gut bacteria with single-cell long-read sequencing

This study develops a single-cell long-read sequencing workflow to generate complete bacterial genomes from uncultured human gut bacteria, revealing structural diversity and phage insertions within species.

Single-cell metabolite detection and genomics reveals uncultivated talented producer

This study identifies an uncultivated bacterium as a producer of antifungal metabolites using Raman microscopy and single-cell sequencing in a sponge microbiome.

Identification of two cancer stem cell-like populations in triple-negative breast cancer xenografts

The paper identifies two cancer stem cell-like populations in TNBC xenografts using transcriptomic analysis and confirms their presence in patient data, suggesting potential as biomarkers and implications for drug resistance.

Recovery of high-quality assembled genomes via metagenome binning guided with single-cell amplified genomes

This paper introduces MetaSAG, a method using single-cell genomes to improve metagenome binning, resulting in higher quality and strain-resolved microbial genomes from complex communities.

Single-cell genomics of uncultured bacteria reveals dietary fiber responders in the mouse gut microbiota

This study develops a single-cell genomic sequencing technique to identify bacterial responders to dietary fiber in the mouse gut microbiota, revealing metabolic pathways and functional lineages involved in fiber fermentation.

Time-lapse single-cell transcriptomics reveals modulation of histone H3 for dormancy breaking

The paper uses time-lapse single-cell transcriptomics to show histone H3 gene expression fluctuation is crucial for breaking dormancy in fission yeast spores.