Author

J. R. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Ecology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

A. J. Arribas· 2 shared F. Bertoni· 2 shared A. A. Halberstam· 1 shared A. A. Mensah· 1 shared A. Adeniran· 1 shared A. Bunn· 1 shared A. Calaway· 1 shared A. Correa· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersCancer Biology

A. J. Arribas

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Author profile →

7 papers

Recent·Most cited

FGF-21 Conducts a Liver-Brain-Kidney Axis to Promote Renal Cell Carcinoma

Z. Li, X. Zhang, W. Zhu, C. Zhang, K. Sadak, A. A. Halberstam, J. R. Brown, C. J. Perry, A. Bunn, D. A. Braun, A. Adeniran, S. Lee, A. Wang, R. J. Perry

This study identifies FGF-21's role in promoting renal gluconeogenesis through a liver-brain-kidney axis, linking it to accelerated renal cell carcinoma progression and suggesting Adrb2 blockade as a potential therapy.

bioRxiv · Apr 12, 2023 · PreprintPhysiology

Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-Institutional Prospective Cohort Evaluation

L. Bukavina, R. Ginwala, M. Sindhani, M. Prunty, D. Geynisman, G. Pooja, H. Valentine, A. Calaway, J. R. Brown, A. Correa, K. Mishra, R. Pominville, E. Plimack, A. Kutikov, M. Ghannoum, , P. H. Abbosh

The paper evaluates the gut microbiome's role in predicting neoadjuvant chemotherapy response in urothelial carcinoma, finding microbial community signatures outperform clinical variables in prediction.

bioRxiv · Jan 21, 2023Cancer Biology

ERBB4-mediated signaling is a mediator of resistance to BTK and PI3K inhibitors in B cell lymphoid neoplasms

A. J. Arribas, S. Napoli, L. Cascione, L. Barnabei, G. Sartori, E. Cannas, E. Gaudio, C. Tarantelli, A. A. Mensah, F. Spriano, A. Zucchetto, F. M. Rossi, A. Rinaldi, M. Castro de Moura, S. Jovic, , F. Bertoni

This study identifies ERBB4-mediated signaling as a mechanism of resistance to BTK and PI3K inhibitors in B cell lymphoid neoplasms and shows that targeting ERBB signaling can restore sensitivity.

bioRxiv · Jan 1, 2023Cancer Biology

Functional testing of PI3K inhibitors stratifies responders to idelalisib and identifies treatment vulnerabilities in idelalisib-refractory/intolerant chronic lymphocytic leukemia

Y. Yin, P. Athanasiadis, L. Karlsen, A. Urban, I. Murali, S. M. Fernandes, A. J. Arribas, A. K. Hilli, K. Tasken, F. Bertoni, A. R. Mato, E. Normant, J. R. Brown, G. E. Tjonnfjord, T. Aittokallio, S. S. Skanland

This study uses ex vivo drug sensitivity testing to identify treatment responses and vulnerabilities in chronic lymphocytic leukemia patients, showing that pan-PI3Ki and combinations with venetoclax can be effective in idelalisib-refractory/intolerant cases.

bioRxiv · Apr 14, 2022 · PreprintCancer Biology

Universal rules of life: metabolic rates, biological times and the equal fitness paradigm

J. R. Burger, C. Hou, C. Hall, J. R. Brown

The paper reviews and extends the equal fitness paradigm to link metabolism, energy allocation, and universal rules of life across ecological and evolutionary scales.

Ecology Letters · Apr 21, 2021Peer-reviewedEcology

Comparison of SARS-CoV2 N gene real-time RT-PCR targets and commercially available mastermixes

J. R. Brown, D. O'Sullivan, R. P. Pereira, A. S. Whale, E. Busby, J. Huggett, K. Harris

The paper compares four RT-PCR mastermixes and three N gene assays for SARS-CoV-2 detection, finding the N2 assay most sensitive and Takara mastermix best at low detection limits.

bioRxiv · Apr 17, 2020Microbiology

Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to graft-versus-leukemia

P. Bachireddy, C. Ennis, V. Nguyen, K. Clement, S. H. Gohil, S. A. Shukla, J. Forman, N. Barkas, S. Freeman, N. Bavli, L. Elagina, I. Leshchiner, A. W. Mohammad, L. Z. Rassenti, T. J. Kipps, , C. J. Wu

The paper investigates the evolutionary trajectories of chronic lymphocytic leukemia cells during resistance to graft-versus-leukemia, finding distinct genetic and epigenetic dynamics post-transplant compared to chemotherapy.

bioRxiv · Apr 9, 2020Cancer Biology