J. R. Colca

Mitochondrial Pyruvate Carrier Inhibition Initiates Metabolic Crosstalk to Stimulate Branched Chain Amino Acid Catabolism

This study shows that inhibiting the mitochondrial pyruvate carrier reduces branched chain amino acid (BCAA) levels and phosphorylation of BCKDH by activating AMPK/mTOR signaling in patients with NASH and in vitro models.

MSDC-0602K, A Novel Insulin-Sensitizer Improves Insulinemia and Fatty Liver Disease Alone and in Addition to Liraglutide in Mice

This study evaluates a novel insulin-sensitizer MSDC-0602K in combination with Liraglutide, showing improved glycemia and liver disease in diabetic and NASH mouse models.