Author

N. M. Niemi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Scientific Communication & Education· 3 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:metabolism & bioenergetics· 4 Research Focus:cell signaling & trafficking· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:benchmarking· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2

Frequent Co-Authors

A. W. Bisson Filho· 3 shared C. T. Smith· 3 shared S. Sarabipour· 3 shared A. D. Attie· 2 shared A. Ibrahim· 2 shared D. J. Pagliarini· 2 shared J. J. Coon· 2 shared K. Clark· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersScientific Communication & Education

A. W. Bisson Filho

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

PPTC7 limits mitophagy through proximal and dynamic interactions with BNIP3 and NIX

L. Wei, M. O. Gok, J. D. Svoboda, M. Forny, J. R. Friedman, N. M. Niemi

This paper shows that PPTC7 limits mitophagy by interacting with BNIP3 and NIX, promoting their proteasomal degradation through dynamic, proximal associations.

bioRxiv · Jan 24, 2024 · PreprintBiochemistry

Insights from a survey of mentorship experiences by graduate and postdoctoral researchers

S. Sarabipour, N. M. Niemi, S. J. Burgess, C. T. Smith, A. W. Bisson Filho, A. Ibrahim, K. Clark

This study surveys graduate and postdoctoral researchers to assess mentorship quality, finding dissatisfaction in 25-45% of respondents and identifying common issues and strategies to improve mentorship.

bioRxiv · May 5, 2023 · PreprintScientific Communication & Education

Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy

N. M. Niemi, L. R. Serrano, L. K. Muehlbauer, C. Balnis, K.-L. Kozul, E. H. Rashan, E. Shishkova, K. L. Schueler, M. P. Keller, A. D. Attie, J. Pagan, J. J. Coon, D. J. Pagliarini

This study shows that Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy, leading to metabolic defects and early lethality in mice.

bioRxiv · Feb 28, 2023Biochemistry

The faculty-to-faculty mentorship experience: a survey on challenges and recommendations for improvements

S. Sarabipour, N. M. Niemi, S. J. Burgess, C. T. Smith, A. W. Bisson Filho, A. Ibrahim, K. Clark

This study surveys early- and mid-career faculty to assess mentorship experiences, identifying challenges and recommending improvements for faculty mentorship programs.

bioRxiv · Oct 17, 2022Scientific Communication & Education

Mitochondrial Pyruvate Carrier Inhibition Initiates Metabolic Crosstalk to Stimulate Branched Chain Amino Acid Catabolism

D. Ferguson, S. J. Eichler, N. K. H. Yiew, J. R. Colca, K. Cho, A. J. Lutkewitte, G. J. Patti, K. S. McCommis, N. M. Niemi, B. N. Finck

This study shows that inhibiting the mitochondrial pyruvate carrier reduces branched chain amino acid (BCAA) levels and phosphorylation of BCKDH by activating AMPK/mTOR signaling in patients with NASH and in vitro models.

bioRxiv · May 11, 2022Physiology

The pyruvate dehydrogenase complex regulates mitophagic selectivity and matrix protein phosphorylation

P. Kolitsida, V. Nolic, M. Stumpe, J. Zhou, N. M. Niemi, J. Dengjel, H. Abeliovich

The paper identifies a novel role of the pyruvate dehydrogenase complex in regulating mitophagic selectivity independently of its enzymatic activity.

bioRxiv · Mar 16, 2022 · PreprintCell Biology

Insights from a survey-based analysis of the academic job market

J. D. Fernandes, S. Sarabipour, C. T. Smith, N. M. Niemi, N. M. Jadavji, A. J. Kozik, A. S. Holehouse, V. Pejaver, O. Symmons, A. W. Bisson Filho, A. Haage

This study analyzes survey data from faculty job applicants to assess how various metrics correlate with hiring outcomes and highlights issues with the academic job application process.

bioRxiv · Dec 2, 2019Scientific Communication & Education

Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis

N. M. Niemi, G. M. Wilson, K. A. Overmyer, F.- N. Vogtle, D. C. Lohman, K. L. Schueler, A. D. Attie, C. Meisinger, J. J. Coon, D. J. Pagliarini

This study shows that Pptc7 is essential for mitochondrial metabolism and biogenesis, as its deletion in mice causes metabolic defects and early death.

bioRxiv · Sep 25, 2018Biochemistry