Author

S. J. Eichler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:clinical cohort / trial· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. J. Lutkewitte· 2 shared B. N. Finck· 2 shared D. Ferguson· 2 shared A. LaPoint· 1 shared G. J. Patti· 1 shared G. Patti· 1 shared J. D. Schilling· 1 shared J. R. Colca· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPhysiology

A. J. Lutkewitte

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2 papers

Recent·Most cited

Mitochondrial Pyruvate Carrier Inhibition Attenuates Hepatic Stellate Cell Activation and Liver Injury in a Mouse Model of Metabolic Dysfunction-associated Steatotic Liver Disease

M. Habibi, D. Ferguson, S. J. Eichler, M. M. Chan, A. LaPoint, T. M. Shew, M. He, A. J. Lutkewitte, J. D. Schilling, K. Y. Cho, G. Patti, B. N. Finck

bioRxiv · Feb 13, 2023 · PreprintPhysiology

Mitochondrial Pyruvate Carrier Inhibition Initiates Metabolic Crosstalk to Stimulate Branched Chain Amino Acid Catabolism

D. Ferguson, S. J. Eichler, N. K. H. Yiew, J. R. Colca, K. Cho, A. J. Lutkewitte, G. J. Patti, K. S. McCommis, N. M. Niemi, B. N. Finck

This study shows that inhibiting the mitochondrial pyruvate carrier reduces branched chain amino acid (BCAA) levels and phosphorylation of BCKDH by activating AMPK/mTOR signaling in patients with NASH and in vitro models.

bioRxiv · May 11, 2022Physiology