Author

J. S. Saad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. Brandt-Almeida· 2 shared G. Palmisano· 2 shared G. S. de Oliveira· 2 shared L. R. Fernandes· 2 shared M. Cortez· 2 shared M. R. Larsen· 2 shared S. N. Mule· 2 shared A. N. Riegler· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

D. Brandt-Almeida

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The protein map of the protozoan parasite Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis and Leishmania (Leishmania) infantum during growth phase transition and temperature stress

S. N. Mule, J. S. Saad, I. P. Sauter, L. R. Fernandes, G. S. de Oliveira, D. Quina, F. T. Tano, D. Brandt-Almeida, G. Padron, B. S. Stolf, M. R. Larsen, M. Cortez, G. Palmisano

This study analyzes the proteomes of three Leishmania species under different growth phases and temperature stress to identify molecular changes during parasite-host interactions.

bioRxiv · Nov 27, 2023 · PreprintMicrobiology

Leishmaniinae: evolutionary inferences based on protein expression profiles (PhyloQuant) congruent with phylogenetic relationships among Leishmania, Endotrypanum, Porcisia, Zelonia, Crithidia, and Leptomonas

S. N. Mule, E. V. Aleman, L. R. Fernandes, J. S. Saad, G. S. de Oliveira, D. Martins, C. B. Angeli, D. Brandt-Almeida, M. Cortez, M. R. Larsen, J. J. Shaw, M. M. G. Teixeira, G. Palmisano

The paper infers evolutionary relationships among Leishmaniinae parasites using protein expression profiles, finding results congruent with established DNA-based phylogeny.

bioRxiv · Sep 22, 2023 · PreprintEvolutionary Biology

Structural basis for human T-cell leukemia virus type 1 Gag targeting to the plasma membrane for assembly

D. Herrmann, L. W. Zhou, H. M. Hanson, N. A. Willkomm, L. M. Mansky, J. S. Saad

This study determines the structural basis of HTLV-1 Gag targeting to the plasma membrane, showing that myr(-)MA binds to PI(4,5)P2 and PS through charge-charge interactions and a basic patch of lysine and arginine residues.

bioRxiv · Apr 8, 2021Microbiology

Capsule protects against intracellular killing and enables vascular endothelial cell translocation during invasive pneumococcal disease

T. Brissac, E. Martinez, K. L. Kruckow, A. N. Riegler, F. Ganaie, H. Im, S. Bakshi, N. M. Arroyo-Diaz, B. Spencer, J. S. Saad, M. H. Nahm, C. J. Orihuela

This study shows that pneumococcal capsule protects bacteria from oxidative stress in host cells and enhances disease severity by promoting intracellular survival and translocation.

bioRxiv · Feb 10, 2021 · PreprintMicrobiology

Structural characterization of HIV-1 matrix mutants implicated in envelope incorporation

G. N. Eastep, R. H. Ghanam, T. J. Green, J. S. Saad

This study investigates how specific mutations in HIV-1 matrix (MA) affect its trimerization and Env incorporation, revealing structural changes and hydrogen bonding that stabilize the trimer form.

bioRxiv · Oct 14, 2020Biochemistry