H. Im

PspA-mediated aggregation protects Streptococcus pneumoniae against desiccation on fomites

This study shows PspA-mediated aggregation of Streptococcus pneumoniae enhances desiccation survival on fomites and transmission to new hosts.

In vitro broad-spectrum antiviral activity of MIT-001, a mitochondria-targeted reactive oxygen species scavenger, against severe acute respiratory syndrome coronavirus 2 and multiple zoonotic viruses

This study evaluates MIT-001's antiviral activity against SARS-CoV-2 and zoonotic viruses in vitro, showing inhibition of viral replication and restoration of antioxidant gene expression.

Engineered superinfective Pf phage prevents dissemination of Pseudomonas aeruginosa in a mouse burn model

The paper engineers a superinfective Pf phage to prevent Pseudomonas aeruginosa dissemination in burn wounds, achieving bacterial clearance and survival in mice.

Non-contact microfluidic analysis of the stiffness of single large extracellular vesicles from IDH1-mutated glioblastoma cells

This study uses non-contact microfluidics to measure stiffness differences in large EVs from IDH1-mutated and wild-type glioblastoma cells, showing the mutation increases EV stiffness and saturated lipid content.

Clinical and immunological signatures of severe COVID-19 in previously healthy patients with clonal hematopoiesis

This study identifies clonal hematopoiesis as an independent risk factor for severe COVID-19 in previously healthy patients, revealing distinct immunological and epigenetic signatures.

Capsule protects against intracellular killing and enables vascular endothelial cell translocation during invasive pneumococcal disease

This study shows that pneumococcal capsule protects bacteria from oxidative stress in host cells and enhances disease severity by promoting intracellular survival and translocation.

Deep transfer learning-based hologram classification for molecular diagnostics

This paper develops a deep transfer learning method to classify LDIH holograms without image reconstruction, enabling low-cost point-of-care diagnostics.