Author

J. Trent

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:whole-exome sequencing· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

K. Drenner· 2 shared K. Sivaprakasam· 2 shared V. Zismann· 2 shared W. P. D. Hendricks· 2 shared A. Nazareno· 1 shared A. Ruhe· 1 shared A. Sekulic· 1 shared A. Weston· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

K. Drenner

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Author profile →

4 papers

Recent·Most cited

State-transition Modeling of Blood Transcriptome Predicts Disease Evolution and Treatment Response in Chronic Myeloid Leukemia

D. E. Frankhouser, R. C. Rockne, L. Uechi, D. Zhao, S. Branciamore, D. O'Meally, J. Irizarry, L. Ghoda, H. Ali, J. Trent, S. Forman, Y.-H. Fu, Y.-H. Kuo, B. Zhang, G. Marcucci

The paper uses transcriptome-based state-transition models to predict CML disease progression and treatment response using time-sequential blood samples from mice.

bioRxiv · Oct 11, 2023Cancer Biology

The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer

R. Soldi, T. Ghosh Halder, A. Weston, T. Thode, K. Drenner, R. Lewis, M. R. Kaadige, S. Srivastava, S. Daniel Ampanattu, R. Rodriguez del Villar, J. D. Lang, H. Vankayalapati, B. Weissman, J. Trent, W. Hendricks, S. Sharma

This study shows that the LSD1 inhibitor SP-2577 enhances anti-tumor immunity and PD-L1 expression in SWI/SNF-mutated ovarian cancer models.

bioRxiv · Jan 10, 2020Cancer Biology

Identification of frequent activating HER2 mutations in primary canine pulmonary adenocarcinoma

G. Lorch, K. Sivaprakasam, V. Zismann, N. Perdigones, T. Contente-Cuomo, A. Nazareno, S. Facista, S. Wong, K. Drenner, W. S. Liang, J. M. Amann, S. L. Sinicropi-Yao, M. J. Koenig, K. La Perle, T. G. Whitsett, , W. P. D. Hendricks

This study identifies HER2 mutations in canine pulmonary adenocarcinomas, finding V659E mutations in 38% of cases and their association with drug sensitivity.

bioRxiv · Feb 25, 2019 · PreprintCancer Biology

Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine melanoma by integrated comparative genomic analysis

W. P. D. Hendricks, V. Zismann, K. Sivaprakasam, C. Legendre, K. Poorman, W. Tembe, J. Kiefer, W. Liang, V. DeLuca, M. Stark, A. Ruhe, R. Froman, N. Duesbury, M. Washington, J. Aldrich, , J. Trent

This study identifies somatic PTPRJ mutations and dysregulated pathways in canine melanoma through genomic analysis, revealing similarities with human melanoma subtypes and potential therapeutic targets.

bioRxiv · Sep 30, 2017Cancer Biology