A. Weston

Development and validation of a high throughput screening platform to enable target identification in skeletal muscle cells from Duchenne Muscular Dystrophy (DMD) patients

The paper develops and validates a high throughput screening platform using morphological profiling to predict DMD disease phenotype in patient-derived myotubes.

A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma stimulated human cells

The paper identifies a heterotrimeric complex of Toxoplasma proteins that enhances parasite survival in IFNγ-activated human cells.

The Aspartyl Protease Ddi1 Is Essential for Erythrocyte Invasion by the Malaria Parasite

This study shows that PfDdi1 proteolytic activity is essential for Plasmodium falciparum erythrocyte invasion and identifies it as a potential antimalarial target.

Citizen science, cells and CNNs - deep learning for automatic segmentation of the nuclear envelope in electron microscopy data, trained with volunteer segmentations

This paper trains a deep learning model to automatically segment the nuclear envelope in electron microscopy data using volunteer annotations from a citizen science project.

The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer

This study shows that the LSD1 inhibitor SP-2577 enhances anti-tumor immunity and PD-L1 expression in SWI/SNF-mutated ovarian cancer models.

Engineering transplantable jejunal mucosal grafts using primary patient-derived organoids from children with intestinal failure

This study develops a method to create transplantable jejunal mucosal grafts using patient-derived organoids and decellularized scaffolds, demonstrating functional grafts in vitro and in vivo.