S. Forman

State-transition Modeling of Blood Transcriptome Predicts Disease Evolution and Treatment Response in Chronic Myeloid Leukemia

The paper uses transcriptome-based state-transition models to predict CML disease progression and treatment response using time-sequential blood samples from mice.

Local CpG-Stat3 siRNA treatment improves antitumor effects of checkpoint inhibitors

This study shows that local CpG-Stat3 siRNA treatment enhances checkpoint inhibitor efficacy in mouse tumor models by improving T-cell responses.

Oligo-PROTAC strategy for cell-selective and targeted degradation of activated STAT3

This paper develops a PROTAC-based strategy to selectively degrade activated STAT3 in specific cell types, showing efficacy in reducing STAT3 levels and tumor growth in lymphoma models.

Dexamethasone Enhances CAR T Cell Persistence and Function by Upregulating Interleukin 7 Receptor

This study shows dexamethasone enhances CAR T cell persistence and function by upregulating IL7R, improving anti-tumor efficacy in vivo.

CAR T cell therapy drives endogenous locoregional T cell dynamics in a responding patient with glioblastoma

This study tracks T cell dynamics in a glioblastoma patient undergoing CAR T cell therapy, showing endogenous T cells are activated and contribute to treatment response.

High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

This study uses high-throughput phenotyping of knockout mice to identify genetic factors and structural patterns influencing immune variation.

State-Transition Analysis of Time-Sequential Gene Expression Identifies Critical Points That Predict Leukemia Development

The paper models leukemia transcriptome dynamics in a state-space to identify critical points that predict disease development.

Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection

This study shows that IL-10R signaling in immune cells is essential for controlling whipworm infection, microbiota homeostasis, and preventing immunopathology in mice.