J. Vazquez

Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy

This study shows that myosin inhibition with mavacamten is effective in treating HCM caused by both truncating and missense variants in MYBPC3, despite different pathomechanisms.

Phosphatase-independent activity of smooth-muscle calcineurin orchestrates a gene expression program leading to hypertension

This study shows that smooth-muscle calcineurin, independent of its phosphatase activity, drives a gene expression program that causes hypertension.

Lack of p38 activation in T cells increases IL-35 production and protects against obesity by promoting thermogenesis

This study shows that inhibiting p38 in T cells increases IL-35 production, which enhances thermogenesis and protects against obesity.

Na+/H+ antiporter activity by respiratory complex I controls mitochondrial Δ{psi} and is impaired in LHON disease

The paper identifies the P-module of complex I as the Na+/H+ antiporter in mitochondria, showing its role in maintaining ΔΨmt and its dysfunction in LHON disease.

Incongruence between transcriptional and vascular pathophysiological cell states

This study compares the vascular phenotypes and transcriptional states of Notch pathway mutants, revealing discrepancies between molecular changes and vascular pathology.

Efficacy of Biofilm Disrupters Against Candida auris and Other Candida species

This study evaluates biofilm disrupters against Candida auris and other Candida species, finding they are more effective than chlorhexidine against certain isolates.

Conserved cysteines in titin sustain the mechanical function of cardiomyocytes

The paper identifies that mutations in conserved titin cysteines disrupt mechanoredox control, leading to dilated cardiomyopathy in humans.

Respiratory supercomplexes provide metabolic efficiency in zebrafish

This study identifies respiratory supercomplexes in zebrafish and shows that their assembly by SCAF1 improves metabolic efficiency and bioenergetics.

Efficient and specific Ly6G+ cell depletion: A change in the current practices toward more relevant functional analyses of neutrophils

The paper compares anti-Gr1 and anti-Ly6G antibodies for neutrophil depletion, showing anti-Ly6G's inefficacy in C57BL/6 mice but its potential for specific depletion when combined with a secondary antibody.

ECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

This study shows caveolin-1 regulates exosome biogenesis and cargo sorting, driving ECM deposition and tumor cell invasiveness through cholesterol-dependent mechanisms.