Author

E. Calvo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Biochemistry· 2 Cell Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Organism:C. elegans· 1

Frequent Co-Authors

J. Vazquez· 5 shared I. Martin-Martin· 2 shared J. A. Enriquez· 2 shared M. R. Pricolo· 2 shared N. Vicente· 2 shared P. C. Valenzuela-Leon· 2 shared P. Hernansanz-Agustin· 2 shared A. Bak· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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5 shared papersPhysiology

J. Vazquez

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Dysregulated Skeletal Muscle Myosin Super-relaxation and Energetics in Type II Diabetes

C. T. Lewis, R. Moreno-Justicia, L. Savoure, E. Calvo, A. Bak, J. Laitila, R. A. E. Seaborne, S. Larsen, H. Iwamoto, M. Cefis, J. A. Morais, G. Gouspillou, J. Alegre-Cebollada, T. J. Hawke, J. Vazquez, , J. Ochala

This study investigates altered myosin super-relaxation and energy metabolism in type II diabetes using muscle biopsies and proteomic analyses, finding increased super-relaxation and reduced ATP demand.

bioRxiv · Jun 12, 2024 · PreprintCell Biology

ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression

S. Elowe, D. K. Prifti, E. Calvo, A. Lauzier, C. Garand, R. Devillers, S. Roy, A. dos Santos, L. Descombes, F. Bordeleau

This study shows TEM4 regulates the cell cycle by controlling G1 progression through modulation of p21waf1/cip1 and cyclin B levels.

bioRxiv · Apr 14, 2024Cell Biology

Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy

L. Sen Martin, A. Fernandez Trasancos, M. A. Lopez Unzu, D. Pathak, A. Ferrarini, V. Labrador Cantarero, D. Sanchez Ortiz, M. R. Pricolo, N. Vicente, D. Velazquez Carreras, L. Sanchez Garcia, J. A. Nicolas Avila, M. Sanchez Diaz, S. Schlossarek, L. Cusso, , J. Alegre Cebollada

This study shows that myosin inhibition with mavacamten is effective in treating HCM caused by both truncating and missense variants in MYBPC3, despite different pathomechanisms.

bioRxiv · Mar 22, 2024Physiology

Na+/H+ antiporter activity by respiratory complex I controls mitochondrial Δ{psi} and is impaired in LHON disease

P. Hernansanz-Agustin, C. Morales-Vidal, E. Calvo, P. Natale, Y. Marti-Mateos, S. Jaroszewicz, J. L. Cabrera-Alarcon, I. Lopez-Montero, J. Vazquez, J. A. Enriquez

The paper identifies the P-module of complex I as the Na+/H+ antiporter in mitochondria, showing its role in maintaining ΔΨmt and its dysfunction in LHON disease.

bioRxiv · May 30, 2023 · PreprintBiochemistry

Anopheles salivary apyrase regulates blood meal hemostasis and drives malaria parasite transmission

Z. R. Pala, T. L. Alves e Silva, M. Minai, B. Crews, E. Patino-Martinez, C. Carmona-Rivera, P. C. Valenzuela-Leon, I. Martin-Martin, Y. Flores-Garcia, R. E. Cachau, N. Srivastava, I. N. Moore, D. A. Alves, M. J. Kaplan, E. Fischer, , J. Vega-Rodriguez

This study shows that Anopheles salivary apyrase promotes Plasmodium transmission by modulating hemostasis during blood feeding.

bioRxiv · May 22, 2023 · PreprintMicrobiology

The salivary protein Saglin facilitates efficient midgut colonization of Anopheles mosquitoes by malaria parasites

D. Klug, A. Gautier, E. Calvo, E. Marois, S. A. Blandin

This study shows that the salivary protein Saglin aids Plasmodium colonization of the mosquito midgut but not salivary glands, and is ingested with blood to affect parasite development.

bioRxiv · Apr 25, 2022Microbiology

Conserved cysteines in titin sustain the mechanical function of cardiomyocytes

E. Herrero-Galan, F. Dominguez, I. Martinez-Martin, C. Sanchez-Gonzalez, N. Vicente, L. Lalaguna, E. Bonzon-Kulichenko, E. Calvo, E. Gonzalez-Lopez, M. Cobo-Marcos, B. Bornstein, A. Briceno, J. P. Ochoa, J. M. Garcia-Aznar, C. Suay-Corredera, , Aleg

The paper identifies that mutations in conserved titin cysteines disrupt mechanoredox control, leading to dilated cardiomyopathy in humans.

bioRxiv · Sep 5, 2020Physiology

Novel function acquired by the Culex quinquefasciatus mosquito D7 salivary protein enhances blood feeding on mammals

I. Martin-Martin, A. Paige, P. C. Valenzuela-Leon, A. Gittis, O. Kern, B. Bonilla, A. C. Chagas, S. Ganesan, D. Garboczi, E. Calvo

This paper identifies a novel ADP-binding function in CxD7L1, a D7 salivary protein from Culex quinquefasciatus mosquitoes, which enhances blood feeding by scavenging ADP to inhibit platelet aggregation.

bioRxiv · Jan 24, 2020Biochemistry

Respiratory supercomplexes provide metabolic efficiency in zebrafish

C. Garcia-Poyatos, S. Cogliati, E. Calvo, P. Hernansanz-Agustin, S. Lagarrigue, R. Magini, M. Botos, X. Langa, F. Amati, J. Vazquez, N. Mercader, J. A. Enriquez

This study identifies respiratory supercomplexes in zebrafish and shows that their assembly by SCAF1 improves metabolic efficiency and bioenergetics.

bioRxiv · Oct 25, 2019Physiology