Author

A. J. Kowaltowski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 9 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Research Focus:metabolism & bioenergetics· 8 Organism:mouse· 8 Research Focus:cell type annotation· 6 Assay:metabolomics· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:cancer & tumor microenvironment· 3 Assay:proteomics· 3

Frequent Co-Authors

C. C. Caldeira da Silva· 4 shared E. A. Vilas-Boas· 4 shared J. D. Serna· 3 shared J. V. Cabral-Costa· 3 shared A. Bruni-Cardoso· 2 shared P. Abreu· 2 shared A. Almeida· 1 shared A. B. Chaves Filho· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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4 shared papersBiochemistry

C. C. Caldeira da Silva

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11 papers

Recent·Most cited

A practical and robust method to evaluate metabolic fluxes in pancreatic islets

D. S. Rocha, A. C. Manucci, A. Bruni-Cardoso, A. J. Kowaltowski, E. A. Vilas-Boas

This paper develops a practical and robust method to assess primary pancreatic islet metabolic fluxes using standard Seahorse equipment, showing reliable respiration and functional responses in mouse and rat islets.

bioRxiv · Jul 25, 2023 · PreprintBiochemistry

Mitochondrial Sodium/Calcium Exchanger (NCLX) Regulates Basal and Starvation-Induced Autophagy Through Calcium Signaling

V. de Miranda Ramos, J. D. Serna, E. A. Vilas-Boas, J. V. Cabral-Costa, F. M. da Cunha, T. Kataura, V. I. Korolchuk, A. J. Kowaltowski

This study shows that NCLX regulates autophagy via calcium signaling, with NCLX knockdown impairing basal and starvation-induced autophagy.

bioRxiv · Mar 17, 2023 · PreprintCell Biology

Mitochondrial sodium/calcium exchanger NCLX regulates glycolysis in astrocytes, impacting on cognitive performance

J. V. Cabral-Costa, C. Vicente-Gutierrez, J. Agulla, R. Lapresa, J. W. Elrod, A. Almeida, J. P. Bolanos, A. J. Kowaltowski

This study shows that NCLX in astrocytes affects glycolysis and cognitive performance, with different impacts based on cell type.

bioRxiv · Sep 16, 2022Biochemistry

Adiponectin Reverses Beta-Cell Damage and Impaired Insulin Secretion Induced by Obesity

A. C. Munhoz, J. D. C. Serna, E. A. Vilas-Boas, C. C. Caldeira da Silva, T. G. dos Santos, F. C. Mosele, S. L. Felisbino, V. R. Martins, A. J. Kowaltowski

This study shows that adiponectin protects beta-cells from obesity-induced damage and restores insulin secretion by reversing mitochondrial dysfunction and oxidative phosphorylation impairment.

bioRxiv · Jul 22, 2022Biochemistry

Goldilocks calcium and the mitochondrial respiratory chain: too much, too little, just right

E. A. Vilas-Boas, J. V. Cabral-Costa, V. M. Ramos, C. C. Caldeira da Silva, A. J. Kowaltowski

This study quantifies how different calcium concentrations affect mitochondrial respiration in mouse liver mitochondria and hepatocytes, finding an optimal range for oxidative phosphorylation.

bioRxiv · Apr 12, 2022 · PreprintBiochemistry

Regulation of Kidney Mitochondrial Function by Caloric Restriction

J. D. Serna, A. G. Amaral, C. C. Caldeira da Silva, A. C. Bonassa, S. L. Menezes, A. J. Kowaltowski

This study investigates how caloric restriction affects mitochondrial function in rat kidneys, finding increased calcium uptake and MICU2 loss, contrasting with effects in brain and liver.

bioRxiv · Dec 29, 2021Biochemistry

Calorie Restriction Maintains Mitochondrial Function and Redox Balance Avoiding Lipidomic Reprogramming during Isoproterenol-Induced Cardiac Hypertrophy

C. E. B. David, A. M. B. Lucas, P. L. O. Cunha, Y. I. P. Viana, M. Y. Yoshinaga, S. Miyamoto, A. B. Chaves Filho, A. J. Kowaltowski, H. T. Facundo

This study shows calorie restriction prevents cardiac hypertrophy-induced lipidomic changes, mitochondrial dysfunction, and oxidative stress in vivo.

bioRxiv · Jul 13, 2021Biochemistry

Increased glycolysis is an early outcome of palmitate-mediated lipotoxicity

P. Kakimoto, A. Zorzano, A. J. Kowaltowski

This study shows that palmitate overload increases glycolysis and causes mitochondrial redox imbalance early in lipotoxicity, without affecting oxygen consumption.

bioRxiv · Jun 10, 2020 · PreprintBiochemistry

Functional Changes Induced by Short Term Caloric Restriction in Cardiac and Skeletal Muscle Mitochondria

J. D. Serna, C. C. Caldeira da Silva, A. J. Kowaltowski

This study examines how short-term caloric restriction affects mitochondrial function in cardiac and skeletal muscle, finding tissue-specific changes in bioenergetics but not in calcium handling or mPT susceptibility.

bioRxiv · Mar 13, 2020Biochemistry

Adult Muscle Stem Cell Self-Renewal Induced by Endurance Exercise is Mediated by Inhibition of Mitochondrial Oxygen Consumption

P. Abreu, A. J. Kowaltowski

This study shows endurance exercise enhances muscle stem cell self-renewal by inhibiting mitochondrial oxygen consumption, improving muscle regeneration and reducing inflammation.

bioRxiv · Nov 18, 2019 · PreprintBiochemistry

Mitochondrial Morphology Regulates Organellar Ca2+ Uptake and Changes Cellular Ca2+ Homeostasis

A. J. Kowaltowski, S. L. Menezes-Filho, E. Assali, I. G. Goncalves, P. Abreu, N. Miller, P. Nolasco, F. R. M. Laurindo, A. Bruni-Cardoso, O. Shirihai

This study shows that mitochondrial morphology affects Ca2+ uptake and cellular Ca2+ homeostasis by altering mitochondrial fusion and fission dynamics.

bioRxiv · May 2, 2019Cell Biology