Author

P. Kemmeren

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:clustering· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Janse· 3 shared F. C. P. Holstege· 3 shared J. Drost· 3 shared J. Y. Hehir-Kwa· 3 shared B. B. J. Tops· 2 shared H. H. D. Kerstens· 2 shared J. H. M. Merks· 2 shared J. J. Molenaar· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

A. Janse

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Author profile →

4 papers

Recent·Most cited

Complex structural variation is prevalent and highly pathogenic in pediatric solid tumors

I. A. E. M. van Belzen, M. C. van Tuil, S. Badloe, A. Janse, E. T. P. Verwiel, M. Santoso, S. de Vos, J. Baker-Hernandez, H. H. D. Kerstens, N. Solleveld-Westerink, M. T. Meister, J. Drost, M. M. van den Heuvel-Eibrink, J. H. M. Merks, J. J. Molenaar, , J. Y. Hehir-Kwa

The paper identifies prevalent and pathogenic complex structural variations in pediatric solid tumors, linking them to adverse clinical outcomes and potential therapeutic targets.

bioRxiv · Sep 19, 2023Cancer Biology

Molecular characterization reveals subclasses of 1q gain in intermediate-risk Wilms tumors

I. A. van Belzen, M. van Tuil, S. Badloe, E. Strengman, A. Janse, E. T. Verwiel, D. F. van der Leest, S. de Vos, J. L. Baker-Hernandez, A. Groenendijk, R. de Krijger, H. H. Kerstens, J. Drost, M. M. van den Heuvel-Eibrink, B. B. Tops, , J. Y. Hehir-Kwa

The paper identifies subclasses of 1q gain in Wilms tumors by integrating genomic and expression data, revealing differences in mutational mechanisms and functional effects.

bioRxiv · Aug 12, 2022 · PreprintCancer Biology

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

M. T. Meister, M. J. A. Groot Koerkamp, T. de Souza, W. B. Breunis, E. Frazer-Mendelewska, M. Brok, J. DeMartino, F. Manders, C. Calandrini, H. H. D. Kerstens, A. Janse, M. E. M. Dolman, S. Eising, K. P. S. Langenberg, M. van Tuil, , F. C. P. Holstege

This study generates tumor organoid models of rhabdomyosarcoma subtypes that closely resemble original tumors and can be used for drug screening and genetic modification.

bioRxiv · Jan 3, 2022Cancer Biology

A comprehensive map of genetic interactions in childhood cancer reveals multiple underlying biological mechanisms

J. T. Daub, S. Amini, D. J. E. Kersjes, X. Ma, N. Jäger, J. Zang, S. M. Pfister, F. C. P. Holstege, P. Kemmeren

The paper identifies genetic interactions in childhood cancers using a statistical pipeline, revealing 15 co-occurring and 27 mutually exclusive gene pairs, with most mechanisms linked to tumor subtypes or pathways.

bioRxiv · Nov 17, 2020Cancer Biology