Targeting of subcellular metabotropic glutamate receptor 5 signaling to modulate pain transmission
Jeffri S. Retamal, Shane D. Hellyer, Paulina D. Ramírez-García, Rocco Latorre, Rina Pokhrel, Thomas Paul Davis, Yifei Zhu, Michael Raymond Whittaker, Jackson Albert Kos, Kelly M O'Sullivan, Nigel W. Bunnett, Wendy L. Imlach, Daniel P. Poole, Karen J. Gregory, Nicholas A. Veldhuis
This study shows that targeting mGlu5 in endosomes improves analgesia by inhibiting nuclear ERK1/2 signaling and reducing neuronal excitability in pain models.
bioRxiv · Jan 30, 2026 · PreprintPharmacology & Toxicology