Author

Jacqueline L. Blankman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Cassandra L. Henry· 2 shared Alberto Russo· 1 shared Anna MoroniiD· 1 shared Benjamin F. CravattiD· 1 shared Bina SantoroiD· 1 shared Bruno N. MelilloiD· 1 shared Carlos GuijasiD· 1 shared Clayton Hutton· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Cassandra L. Henry

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2 papers

Recent·Most cited

Activity-based profiling of primary brain cells identifies covalent allosteric modulators of HCN channels

Elva Ye, Alberto Russo, Roberta Castelli, Gustav T Westlake, Xuan Jiang, Dillon A Spiro, Sara Quejido, Cassandra L. Henry, Jacqueline L. Blankman, Gabriel M. Simon, Bruno N. Melillo, Bina Santoro, Anna Moroni, Benjamin F. Cravatt

bioRxiv · Aug 26, 2026 · PreprintBiochemistry

Base exchange inhibitors of SARM1 form mononucleotide adducts and activate SARM1 in vivo

Holly T. Reardon, Carlos Guijas, Jason R. Clapper, Julia A. Callender, Ellen M. Kozina, Francisco J. Sarabia, Clayton Hutton, Dylan M. Herbst, Taylor Andalis, Luka Perehinets, Cassandra L. Henry, Terry P. Lebold, David A. Kummer, Jacqueline L. Blankman, John J. M. Wiener, , Tarek A. Samad

The paper shows that SARM1 base exchange inhibitors form mononucleotide adducts and paradoxically activate SARM1, leading to increased cADPR and cADPR/NAD ratios in vivo.

bioRxiv · Apr 22, 2025 · PreprintNeuroscience