This study evaluates the pharmacokinetics, biodistribution, and therapeutic efficacy of a trimeric nanobody against SARS-CoV-2 in golden Syrian hamsters, showing that intranasal administration provides effective respiratory exposure and therapeutic benefit.

bioRxiv · Oct 6, 2026 · PreprintMicrobiology

The biodistribution and effect of post-exposure neutralising monoclonal antibody treatment in a mouse model of SARS-CoV-2 infection with viral spread to the brain

Janine Schlaepfer, Simon De Neck, Rebekah Penrice-Randal, Parul Sharma, Adam Kirby, Lee M. Tatham, Eduardo Gallardo Toledo, Joanne Herriott, Edyta Kijak, Joanne Sharp, James P. Stewart, Andrew Owen, Anja Kipar

This study investigates the biodistribution and effects of Ronapreve in a mouse model of SARS-CoV-2 infection, showing it does not reach the brain but reduces viral loads in the lung and brain.

bioRxiv · May 29, 2026 · PreprintPathology

Investigation of anti-SARS CoV-2 multimeric bicyclic peptide inhibitors in a range of pre-clinical therapeutic settings

Maximilian A. J. Harman, Katherine U. Gaynor, Guido Papa, Simone Pellegrino, G.A. Bezerra, Brian McGuinness, Phil Jeffrey, Paul Beswick, Steven J. Stanway, Katerine Van Rietschoten, Liuhong Chen, Ieva Drulyte, Joanne Herriott, Edyta Kijak, Eduardo Gallardo Toledo, , Michael J. Skynner

This paper evaluates the efficacy of multimeric bicyclic peptides as antiviral agents in preclinical SARS-CoV-2 models, showing significant reduction in viral burden across multiple therapeutic settings.

bioRxiv · Oct 3, 2025 · PreprintPharmacology & Toxicology