Author

Jefferson G. Sanchez

Cincinnati Children's Hospital Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Aaron M. ZorniD· 2 shared Daniel O. KecheleiD· 2 shared Mansa KrishnamurthyiD· 2 shared Alexandra K. EicheriD· 1 shared Emily Paul· 1 shared H. Matthew BernsiD· 1 shared Heather A. McCauleyiD· 1 shared Holly M. PolingiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersDevelopmental Biology

Aaron M. ZornORCID

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2 papers

Recent·Most cited

Human organoid modeling of congenital malformations caused by RFX6 mutations reveal an essential role for this transcription factor in establishing and maintaining duodenal identity upstream of PDX1

Jefferson G. Sanchez, Scott Rankin, Emily Paul, Heather A. McCauley, Daniel O. Kechele, Jacob R. Enriquez, Nana‐Hawa Yayah Jones, Siri Atma W. Greeley, Lisa Letourneau-Friedberg, Aaron M. Zorn, Mansa Krishnamurthy, James M. Wells

This study uses human organoids to show RFX6 mutations cause duodenal malformations by disrupting PDX1 and other signaling pathways.

bioRxiv · Nov 9, 2023 · PreprintDevelopmental Biology

Engineering functional human gastrointestinal organoid tissues using the three primary germ layers separately derived from pluripotent stem cells

Alexandra K. Eicher, Daniel O. Kechele, Nambirajan Sundaram, H. Matthew Berns, Holly M. Poling, Lauren E. Haines, Jefferson G. Sanchez, Keishi Kishimoto, Mansa Krishnamurthy, Lu Han, Aaron M. Zorn, Michael A. Helmrath, James M. Wells

The paper develops a method to engineer functional human gastrointestinal organoids by assembling cells from the three primary germ layers, revealing the role of the enteric nervous system in tissue development.

Cell stem cell · Dec 1, 2021Peer-reviewedDevelopmental Biology