A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues
Robert J. Nims, Lara Pferdehirt, Noelani Ho, Alireza Savadipour, Jeremiah Lorentz, Sima Sohi, Jordan G. Kassab, Alison K. Ross, Christopher J. O’Conor, Wolfgang Liedtke, Bo Zhang, Amy L. McNulty, Farshid Guilak
This paper develops a synthetic mechanogenetic gene circuit in engineered tissues that produces a therapeutic drug in response to mechanical loading.
Science Advances · Jan 27, 2021Peer-reviewedSynthetic Biology