Author

Robert J. Nims

Washington University in St. LouisORCID 0000-0002-0856-3188Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Alireza SavadipouriD· 2 shared Amy L. McNultyiD· 2 shared Farshid GuilakiD· 2 shared Wolfgang LiedtkeiD· 2 shared Alison K. RossiD· 1 shared Bo ZhangiD· 1 shared Christopher J. O’ConoriD· 1 shared Fang LiuiD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersSynthetic Biology

Alireza SavadipourORCID

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2 papers

Recent·Most cited

A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues

Robert J. Nims, Lara Pferdehirt, Noelani Ho, Alireza Savadipour, Jeremiah Lorentz, Sima Sohi, Jordan G. Kassab, Alison K. Ross, Christopher J. O’Conor, Wolfgang Liedtke, Bo Zhang, Amy L. McNulty, Farshid Guilak

This paper develops a synthetic mechanogenetic gene circuit in engineered tissues that produces a therapeutic drug in response to mechanical loading.

Science Advances · Jan 27, 2021Peer-reviewedSynthetic Biology

Osteoarthritis: articular chondrocyte inflammatory signaling leads to enhanced gene expression and function of mechanotransduction channel Piezo1 as a pathogenic feedforwardmechanism

Whasil Lee, Robert J. Nims, Alireza Savadipour, Holly A. Leddy, Fang Liu, Amy L. McNulty, Yong Chen, Farshid Guilak, Wolfgang Liedtke

This study identifies a feedforward mechanism in osteoarthritis where IL-1-induced Piezo1 upregulation enhances mechanotransduction and contributes to cartilage damage.

bioRxiv · May 23, 2020 · PreprintMolecular Biology