Alireza Savadipour

This study shows PIEZO1 regulates collagen synthesis in hASCs based on substrate architecture, with YAP/TAZ translocation and collagen production being independent outcomes of PIEZO1 activation.

This study investigates how TRPV4 mutations affect chondrocyte differentiation and identifies altered BMP signaling as a mechanism for skeletal dysplasia.

This paper develops a synthetic mechanogenetic gene circuit in engineered tissues that produces a therapeutic drug in response to mechanical loading.

This study identifies a feedforward mechanism in osteoarthritis where IL-1-induced Piezo1 upregulation enhances mechanotransduction and contributes to cartilage damage.