Strong sustained type I IFN signaling acts cell intrinsically to impair IFNγ responses and cause tuberculosis susceptibility
Stefan A. Fattinger, Parisi Bianca, Roberto A. Chavez, Marian R. Fairgrieve, Ophelia V. Lee, Kristen C. Witt, Jesse J Rodriguez, Elizabeth A Turcotte, Ella C. Brydon, Harmandeep S Dhaliwal, Angus Y. Lee, Dmitri Ivanovich Kotov, Russell E. Vance
The paper shows that sustained type I IFN signaling in infected macrophages impairs IFNγ responses, leading to tuberculosis susceptibility.
Cell Host & Microbe · Aug 14, 2026Peer-reviewedImmunology