Author

Ophelia V. Lee

University of California, BerkeleyORCID 0000-0002-3940-7807Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Angus Y. Lee· 2 shared Dmitri Ivanovich KotoviD· 2 shared Harmandeep S Dhaliwal· 2 shared Kristen C. WittiD· 2 shared Roberto A. Chavez· 2 shared Russell E. VanceiD· 2 shared Stefan A. FattingeriD· 2 shared A. C. LariiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Angus Y. Lee

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Strong sustained type I IFN signaling acts cell intrinsically to impair IFNγ responses and cause tuberculosis susceptibility

Stefan A. Fattinger, Parisi Bianca, Roberto A. Chavez, Marian R. Fairgrieve, Ophelia V. Lee, Kristen C. Witt, Jesse J Rodriguez, Elizabeth A Turcotte, Ella C. Brydon, Harmandeep S Dhaliwal, Angus Y. Lee, Dmitri Ivanovich Kotov, Russell E. Vance

The paper shows that sustained type I IFN signaling in infected macrophages impairs IFNγ responses, leading to tuberculosis susceptibility.

Cell Host & Microbe · Aug 14, 2026Peer-reviewedImmunology

The SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity

Kristen C. Witt, Adam Dziulko, Joohyun An, Filip Pekovic, Arthur Xiuyuan Cheng, Grace Y. Liu, Ophelia V. Lee, David J. Turner, A. C. Lari, Moritz M. Gaidt, Roberto A. Chavez, Stefan A. Fattinger, Preethy Abraham, Harmandeep S Dhaliwal, Angus Y. Lee, , Russell E. Vance

This study identifies SP140's role in regulating IFN-β mRNA stability through RESIST, revealing a dual antiviral and interferon regulatory function.

Nature · Jun 11, 2025Peer-reviewedImmunology