Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling
Megha Amar, Akula Bala Pramod, Nam‐Kyung Yu, Victor Munive Herrera, Lily R. Qiu, Patricia Morán Losada, Pan Zhang, Cleber A. Trujillo, Jacob Ellegood, Jorge Urresti, Kevin K. Chau, Jolene K. Diedrich, Jiaye Chen, Jessica Gutierrez, Jonathan L. Sebat, , Lilia M. Iakoucheva
This study shows that Cul3 haploinsufficiency in mice causes social and cognitive deficits, cortical volume reduction, and cytoskeletal defects, which are rescued by RhoA inhibition.
Molecular Psychiatry · Mar 16, 2021Peer-reviewedNeuroscience