Activation of pro-survival autophagy by a small molecule promoting p62 oligomerisation
Johan Panek, Edward Fielder, Congsing Sun, Steph Crabtree, Tetsushi Kataura, Niall Wilson, Lakshana Baheerathan, Jiangyu Tang, Laura K. Booth, Wyatt W. Yue, Gavin David Richardson, Lauren Holder, Gavin John Miller, Jóhannes Reynisson, Sovan Sarkar, Viktor I. Korolchuk
The paper identifies SQ-1 as a small molecule that activates autophagy by promoting p62 oligomerisation, improving mitochondrial clearance and cell viability in NPC1 disease models.
Journal of Biological Chemistry · Aug 11, 2026Peer-reviewedCell Biology