Microbial metabolism of methotrexate produces a STAT3 signaling molecule that alleviates gut inflammation
Juyeong Cho, Rebecca Danner, Woo Sung Kim, Jonathan Williams, Anshit Singh, Jiyoung A. Han, Jonathan G. Van Vranken, Allison S. Walker, Timothy W. Rhoads, Snehal N. Chaudhari
The paper identifies a gut microbial metabolite of methotrexate that alleviates gut inflammation by promoting mitochondrial STAT3 signaling.
bioRxiv · Mar 12, 2026 · PreprintMicrobiology