Karol S. Balderrama

This study uses spatial transcriptomics and lineage tracing to show how tumor subclones drive microenvironmental changes that promote metastasis in a mouse model.

The paper maps a mesoscale molecular architecture of the human striatum across cell types and age, revealing zonal differences in gene expression and aging effects.

The paper introduces Synapse-seq, a method to link transcriptomes to synaptic architecture by using protein-guided RNA barcoding, revealing new insights into neural connectivity and cell type-specific dendritic structures.

The paper creates a high-resolution cellular atlas of healthy and injured kidney cell states and niches using single-cell and spatial technologies, identifying molecular signatures and pathways related to kidney injury.

Slide-tags enables spatial localization of single nuclei for multi-modal spatial genomics, achieving high-resolution mapping and multiomic profiling in various tissues.

Whole-brain snRNA-seq paired with Slide-seq assigns cell types to each mouse neuroanatomical structure; most clusters need at least three markers to be defined uniquely.