Time-resolved lineage recording reveals a pre-existing, heritable cell state underlying metastatic potential
Jihye Park, Yoojin Chang, Joshua S. Schiffman, Divya Koyyalagunta, Hrishikesh Somayaji, Caden N. McQuillen, Joseph Chan, Quaid Morris, Dan Avi Landau, Hyongbum Henry Kim, Junhong Choi
Ordered lineage recording in lung cancer xenografts shows pre-transplant glycolytic and lineage-heritable expression states predict metastatic colonization, while ENO1 alone predicts onward spread.
bioRxiv · Aug 12, 2026 · PreprintCancer Biology✦ In-depth digest