Ordered lineage recording in lung cancer xenografts shows pre-transplant glycolytic and lineage-heritable expression states predict metastatic colonization, while ENO1 alone predicts onward spread.

bioRxiv · Aug 12, 2026 · PreprintCancer Biology✦ In-depth digest

Relative contribution of gonads and sex chromosomes to sex differences in cell-type gene expression in the mouse medial septum and sex-biased disease risk

Juliana E. Shin, Montgomery Blencowe, Caden N. McQuillen, Haley Hrncir, Xuqi Chen, Graciel Diamante, In Sook Ahn, Guanglin Zhang, Arthur P. Arnold, Allan J. MacKenzie‐Graham, Jason P. Lerch, Armin Raznahan, Xia Yang

The paper investigates the relative impact of gonads and sex chromosomes on sex differences in gene expression in the mouse medial septum and links these differences to sex-biased human diseases.

bioRxiv · Dec 11, 2025 · PreprintNeuroscience

Shared and distinct pathways and networks genetically linked to coronary artery disease between human and mouse

Zeyneb Kurt, Jenny Yeuk‐Ki Cheng, Rio Barrere‐Cain, Caden N. McQuillen, Zara Saleem, Neil Hsu, Nuoya Jiang, Calvin Pan, Oscar Franzén, Simon Koplev, Susanna Sue-Ming Wang, Johan Björkegren, Aldons Jake Lusis, Montgomery Blencowe, Xia Yang

This study identifies shared and distinct genetic pathways between human and mouse in coronary artery disease using multi-omics data and GWAS, showing over 75% shared pathways.

eLife · Aug 10, 2023Peer-reviewedSystems Biology

Relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in tissue gene regulation

Montgomery Blencowe, Xuqi Chen, Yutian Zhao, Yuichiro Itoh, Caden N. McQuillen, Yanjie Han, Benjamin L. Shou, Rebecca McClusky, Karen Reue, Arthur P. Arnold, Xia Yang

The paper investigates the relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in gene regulation in liver and adipose tissues using the FCG mouse model.

Genome Research · Apr 8, 2022Peer-reviewedSystems Biology