Author

Josephine L. Ramirez

Columbia University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Molecular Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:bacteria (other)· 2 Approach:experimental assay· 2 Approach:statistical model· 1

Frequent Co-Authors

Samuel H. SternbergiD· 3 shared Dennis J. ZhangiD· 2 shared Marko JovanovićiD· 2 shared Stephen TangiD· 2 shared Tanner WiegandiD· 2 shared Yanzhe MaiD· 2 shared Alba Herrero del ValleiD· 1 shared Arpita ChakravartiiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMolecular Biology

Samuel H. SternbergORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery

Matthieu Haudiquet, Arpita Chakravarti, Zhiying Zhang, Josephine L. Ramirez, Alba Herrero del Valle, Paul Dominic B. Olinares, Rachel Lavenir, Massilia Aït Ahmed, M. Jason de la Cruz, Brian T. Chait, Samuel H. Sternberg, Aude G. Bernheim, Dinshaw J. Patel

This study reveals the structural basis and evolutionary origin of the Lamassu bacterial immune system, showing its adaptation from DNA repair machinery to detect and respond to viral replication.

Proceedings of the National Academy of Sciences · Nov 18, 2025Peer-reviewedMicrobiology

Antiviral reverse transcriptases reveal the evolutionary origin of telomerase

Stephen Tang, Josephine L. Ramirez, Mario Rodríguez Mestre, Dennis J. Zhang, Megan Wang, Tanner Wiegand, Yanzhe Ma, Marko Jovanović, Rafael Pinilla‐Redondo, Samuel H. Sternberg

The paper identifies DRT10, an antiviral reverse transcriptase, and shows its structural and mechanistic similarities to telomerase, suggesting a bacterial origin for telomerase.

bioRxiv · Oct 16, 2025 · PreprintMolecular Biology

Protein-primed DNA homopolymer synthesis by an antiviral reverse transcriptase

Stephen Tang, Rimantė Žedaveinytė, Nathaniel Burman, Shishir Pandey, Josephine L. Ramirez, Louie M Kulber, Tanner Wiegand, Royce A. Wilkinson, Yanzhe Ma, Dennis J. Zhang, George D. Lampe, Mirela Berisa, Marko Jovanović, Blake Wiedenheft, Samuel H. Sternberg

The paper reveals a novel DNA homopolymer synthesis mechanism by DRT9, triggered by viral infection to induce abortive infection and population-level immunity.

Nature · May 28, 2025Peer-reviewedMolecular Biology