The paper shows that oxidized TRX1 and DPP8/9 stabilize the MIA40-AIFM1 complex during intrinsic apoptosis, promoting NLRP1 restraint and preventing pyroptosis.

bioRxiv · Oct 28, 2026 · PreprintCell Biology

Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery

Matthieu Haudiquet, Arpita Chakravarti, Zhiying Zhang, Josephine L. Ramirez, Alba Herrero del Valle, Paul Dominic B. Olinares, Rachel Lavenir, Massilia Aït Ahmed, M. Jason de la Cruz, Brian T. Chait, Samuel H. Sternberg, Aude G. Bernheim, Dinshaw J. Patel

This study reveals the structural basis and evolutionary origin of the Lamassu bacterial immune system, showing its adaptation from DNA repair machinery to detect and respond to viral replication.

Proceedings of the National Academy of Sciences · Nov 18, 2025Peer-reviewedMicrobiology

Structural basis of ATP-dependent high-fidelity epigenome maintenance

Juncheng Wang, Sandra Catania, Chongyuan Wang, M. Jason de la Cruz, Beiduo Rao, Hiten D. Madhani, Dinshaw J. Patel

The paper reveals the structural mechanism of ATP-dependent DNA methylation by DNMT5, showing how hemimethylated DNA activates the SNF2 ATPase domain and remodels the catalytic pocket for specificity.

bioRxiv · Oct 1, 2021 · PreprintMolecular Biology